|
rs10019009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a functional analysis of rs10019009 via reverse transcription-polymerase chain reaction, alkaline phosphatase (ALP) activity in human osteosarcoma U 2 OS cells.
|
26960368 |
2016 |
|
rs1005464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis also showed that carriers of the G-T-T-G and A-T-T-G haplotypes (rs235764-rs3178250-rs235768-rs1005464) had significant increased risks of osteosarcoma (age-adjusted OR = 1.85, 95% CI of 1.28-2.66 and age-adjusted OR = 1.51, 95% CI of 1.06-2.16) compared with the G-C-T-A haplotype carriers.
|
25391427 |
2015 |
|
rs10208273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown.
|
24984297 |
2014 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present meta-analysis, we aimed to elucidate the associations of TP53 rs1042522 genetic polymorphism with the risk of osteosarcoma or Ewing sarcoma.
|
30833364 |
2019 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These data do not indicate a strong link between variation in TP53 and OS risk, although they provide preliminary evidence of an increased risk of OS associated with variants at IVS2+38 and Pro72Arg.
|
17096406 |
2007 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The study provides evidence supporting the association of MDM2 SNP309 with high-grade osteosarcoma risk in females and shows that TP53 Arg72Pro has a prognostic value for overall survival and EFS in osteosarcoma patients.
|
19451596 |
2009 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that subjects carrying rs12951053 CC genotype and rs1042522</span> GG genotype were significantly associated with risk of OS [odds ratio (OR)=1.68, 95% confidence intervals (CI): 1.05-2.68; OR=1.89, 95% CI: 1.16-3.07] compared with subjects carrying the common genotypes.
|
26045840 |
2015 |
|
rs1047768
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we performed a meta-analysis to determine the strength of the association between eight polymorphisms in the <i>ERCC</i> genes (rs11615, rs3212986, rs2298881, rs13181, rs1799793, rs1800067, rs2296147, and rs1047768) and prognosis of osteosarcoma patients treated with chemotherapy.
|
29950854 |
2018 |
|
rs1047768
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings showed polymorphisms in ERCC5 rs1047768 and MMS19L rs29001322 to be associated with clinical outcome of osteosarcoma patients undergoing chemotherapy.
|
23679317 |
2013 |
|
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, multiple mutations were identified in phosphoinositide-3-kinase (PI3K), catalytic, alpha polypeptide (PIK3CA) (H1047R, E→lysine at codon 545 [E545K], and H→proline at codon 701 [H701P]) that were not observed previously in osteosarcoma.
|
22006429 |
2012 |
|
rs1052667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that ARHGAP35 rs1052667 polymorphism may be associated with osteosarcoma risk and prognosis.
|
25136583 |
2014 |
|
rs1056629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to explore the roles of microRNA-491-5p (miR-491) and its target MMP9 in the control of metastasis of osteosarcoma (OS) as well as how the rs1056629 polymorphism in the 3' untranslated region (3'UTR) of MMP9 compromises the interaction between miR-491 and MMP9.
|
27023472 |
2016 |
|
rs1057519736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, MsMab-1 stained IDH2-R172S-expressing osteosarcoma tissues in immunohistochemistry.
|
24403254 |
2013 |
|
rs1058808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HER2 gene rs1136201 and rs1058808 polymorphisms and haplotype C-T-G-G may be related to osteosarcoma susceptibility in Chinese Han population, indicating that the interaction of gene polrmorphism plays an role in osteosarcoma risk.
|
26464710 |
2015 |
|
rs1060501205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
She was found to have a base pair change (A-->C) at nucleotide 394 resulting in a lysine to glutamine amino acid change at codon 132 (K132Q), which remarkably has never been described in association with either adrenocortical carcinoma or osteosarcoma.
|
18989156 |
2008 |
|
rs1061970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CT genotype and C allele of COL1A1 at rs1061970, and CG genotype and G allele of COL1A1 at rs2075559 are associated with decreased susceptibility to osteosarcoma</span> in the Chinese population.
|
24072491 |
2014 |
|
rs11177386
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this study indicated that the allele-A and genotype-AA of MDM2 c.346G>A genetic variant could be an increased risk factor for the susceptibility to osteosarcoma and might be used as a potential molecular marker for evaluating the risk of osteosarcoma.
|
25551700 |
2015 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.
|
26107220 |
2015 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The <i>ABCB1</i> (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way.
|
30977678 |
2019 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The study provides evidence supporting the association of MDM2 SNP309 with high-grade osteosarcoma risk in females and shows that TP53 Arg72Pro has a prognostic value for overall survival and EFS in osteosarcoma patients.
|
19451596 |
2009 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These data do not indicate a strong link between variation in TP53 and OS risk, although they provide preliminary evidence of an increased risk of OS associated with variants at IVS2+38 and Pro72Arg.
|
17096406 |
2007 |
|
rs1136201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HER2 gene rs1136201 and rs1058808 polymorphisms and haplotype C-T-G-G may be related to osteosarcoma susceptibility in Chinese Han population, indicating that the interaction of gene polrmorphism plays an role in osteosarcoma risk.
|
26464710 |
2015 |
|
rs11556218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.
|
27703190 |
2016 |
|
rs11615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our results suggested that the ERCC1 rs11615 and rs2298881 polymorphisms play important roles in the response to chemotherapy mediated by the DNA repair pathway and in the clinical outcome of osteosarcoma.
|
26345951 |
2015 |
|
rs11615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that ERCC1 rs11615 and ERCC1 rs2298881 genetic polymorphisms are significantly associated with poor response to chemotherapy and unfavourable survival of osteosarcoma.
|
26339355 |
2015 |