|
rs10208273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown.
|
24984297 |
2014 |
|
rs17111750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was designed to determine whether APE1 polymorphisms (rs1130409, rs1760944, rs1760941, rs2275008, rs17111750) are associated with OS.
|
28839218 |
2017 |
|
rs231755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypic association analyses showed that the CTLA4 rs231755 was associated with osteosarcoma susceptibility in the Spanish population.
|
28052683 |
2019 |
|
rs7591996
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown.
|
24984297 |
2014 |
|
rs8103992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An expression quantitative trait locus for cartilage intermediate layer protein 2 (CILP2), rs8103992, was significantly associated with osteosarcoma risk after adjustment for multiple comparisons (odds ratio, 1.35; 95% CI, 1.16-1.56 [P = 7.93×10<sup>-5</sup> and P<sub>adjusted</sub> =.034]).
|
30311632 |
2018 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.
|
26107220 |
2015 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The <i>ABCB1</i> (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way.
|
30977678 |
2019 |
|
rs4148416
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.
|
26107220 |
2015 |
|
rs4148416
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, variants of ABCB1 rs128503, ABCC3 rs4148416, and GSTP1 rs1695 are associated with response to chemotherapy and PFS and OS of osteosarcoma patients; these gene polymorphisms could help in the design of individualized therapy.
|
24996541 |
2014 |
|
rs1223868338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests an association between the Fas exon 3 A>G polymorphism and osteosarcoma risk; however, further study is needed with pediatric controls and a larger sample size.
|
18090928 |
2007 |
|
rs1872328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study replicating the association of ACYP2 variant rs1872328 with cisplatin-induced ototoxicity in patients with osteosarcoma who did not receive potentially ototoxic cranial irradiation.
|
26928270 |
2016 |
|
rs17206779
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown.
|
24984297 |
2014 |
|
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functionality of rs553668 and rs1800544 single nucleotide polymorphism SNPs located in α2A-AR gene was analysed by qPCR expression on bone samples and luciferase reporter assay in human osteosarcoma HOS cells.
|
25818344 |
2015 |
|
rs553668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functionality of rs553668 and rs1800544 single nucleotide polymorphism SNPs located in α2A-AR gene was analysed by qPCR expression on bone samples and luciferase reporter assay in human osteosarcoma HOS cells.
|
25818344 |
2015 |
|
rs1215600806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs1215600806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs1416572796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs143358506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs143358506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested that APE1 rs1760944 polymorphism is associated with decreased risk of developing OS and better survival of OS patients.
|
28839218 |
2017 |
|
rs1052667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that ARHGAP35 rs1052667 polymorphism may be associated with osteosarcoma risk and prognosis.
|
25136583 |
2014 |
|
rs2372536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Even though the role of single nucleotide polymorphisms of ATIC in chemotherapy-induced tumor necrosis has not been investigated yet, the ATIC 347C>G polymorphism may influence the levels of adenosine after MTX treatment, which may affect the histologic response of osteosarcoma.
|
28267080 |
2017 |
|
rs199476133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to identify genes whose expression is altered as a result of the presence of mtDNA mutations, DNA microarray analysis was performed using human 143B osteosarcoma cells harboring 3243A>G [tRNA-Leu (UUR)] and 8993T>G [ATPase6 Leu156Arg] mtDNA mutations associated with MELAS and NARP syndromes (2SD and NARP3-1 cybrid cells), respectively.
|
17276738 |
2007 |
|
rs3787547
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1295925 (OR = 0.85; 95 CI = 0.76-0.94; P = 0.003) and rs3787547 (OR = 1.27; 95 CI = 1.11-1.45; P = 4.0 × 10<sup>-4</sup>) was significantly with OS</span> susceptibility.
|
29595404 |
2018 |
|
rs1005464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis also showed that carriers of the G-T-T-G and A-T-T-G haplotypes (rs235764-rs3178250-rs235768-rs1005464) had significant increased risks of osteosarcoma (age-adjusted OR = 1.85, 95% CI of 1.28-2.66 and age-adjusted OR = 1.51, 95% CI of 1.06-2.16) compared with the G-C-T-A haplotype carriers.
|
25391427 |
2015 |