|
rs121909174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because two cases with homozygous T354P mutation developed multinodular goiters within their second decade of life though they had been maintained in euthyroid state, homozygous T354P mutation alone and/or low intrathyroidal iodide and high serum TSH level in early life might account for tumorigenesis.
|
9709973 |
1998 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess the role in tumorigenesis of the variant (A)8 tract produced by this allele, we undertook a somatic mutation analysis of the region surrounding codon 1307 in colorectal tumors from APC I1307K carriers.
|
9751605 |
1998 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess the role in tumorigenesis of the variant (A)8 tract produced by this allele, we undertook a somatic mutation analysis of the region surrounding codon 1307 in colorectal tumors from APC I1307K carriers.
|
9751605 |
1998 |
|
rs138106763
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, the subclass exemplified by the melanoma-derived N50S mutant may promote tumorigenesis, by both attenuating CDK-inhibitory function and concomitantly activating the proto-oncogenic cyclin D-dependent kinases.
|
9823309 |
1998 |
|
rs866551255
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, the subclass exemplified by the melanoma-derived N50S mutant may promote tumorigenesis, by both attenuating CDK-inhibitory function and concomitantly activating the proto-oncogenic cyclin D-dependent kinases.
|
9823309 |
1998 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings support the hypothesis that MTHFR C677T variants contribute to gastric carcinogenesis, particularly in gastric cardia.
|
11494235 |
2001 |
|
rs1805007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the R151C variant may be involved in melanoma tumorigenesis in a dual manner, both as a determinant of fair skin and as a component in an independent additional pathway.
|
11500806 |
2001 |
|
rs35187787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the fact that this alteration (Ala592Thr) segregated with colon cancer and diffuse gastric cancer in one big family, suggests that this E-cadherin missense alteration, beside predisposing to diffuse gastric cancer, also may play a role in colorectal carcinogenesis.
|
11562785 |
2001 |
|
rs11547328
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.
|
11756559 |
2002 |
|
rs771138120
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.
|
11756559 |
2002 |
|
rs121913507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the signal transduction pathways responsible for oncogenesis by the Asp814Val mutant (KIT(Val814)) are not fully understood.
|
12393643 |
2003 |
|
rs121913682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the signal transduction pathways responsible for oncogenesis by the Asp814Val mutant (KIT(Val814)) are not fully understood.
|
12393643 |
2003 |
|
rs121965039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To probe the mechanism of carcinogenesis of lung cancer at the molecular level and to find potential protein markers involved in the early phase of tumorgenesis, differential proteome analysis on primary passage cell line R15H, and early transformed cell line R15H20 derived from (238)Pu alpha-particle irradiation of human papillomavirus (HPV) 18-immortalized human bronchial epithelial cell line (BEP2D), was carried out using two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF) with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.
|
12548635 |
2003 |
|
rs146755810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To probe the mechanism of carcinogenesis of lung cancer at the molecular level and to find potential protein markers involved in the early phase of tumorgenesis, differential proteome analysis on primary passage cell line R15H, and early transformed cell line R15H20 derived from (238)Pu alpha-particle irradiation of human papillomavirus (HPV) 18-immortalized human bronchial epithelial cell line (BEP2D), was carried out using two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF) with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.
|
12548635 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the study was to investigate the role of MTHFR 677 C-->T gene polymorphism in the tumorigenesis of proximal and distal CLC in a monoinstitutional group of patients in North Italy.
|
12576444 |
2003 |
|
rs1048943
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might play a role in lung carcinogenesis among non-smokers, possibly in combination with the GSTM1 null genotype.
|
12771031 |
2003 |
|
rs11547328
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These data suggest that the changes in the regulatory 'hot-spot' on the CDK4 gene, causing various endocrine tumours in CDK4(R24C/R24C )mice, are not a major factor in sporadic pituitary, insulin beta-cell or Leydig cell tumorigenesis.
|
12904177 |
2003 |
|
rs771138120
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These data suggest that the changes in the regulatory 'hot-spot' on the CDK4 gene, causing various endocrine tumours in CDK4(R24C/R24C )mice, are not a major factor in sporadic pituitary, insulin beta-cell or Leydig cell tumorigenesis.
|
12904177 |
2003 |
|
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, when we used normal colonoscopy controls (E1317Q carrier frequency = 0.3%), the prevalence of E1317Q was significantly increased in CRC patients, in patients with < or =3 adenomas, and in CRC patients with intact mismatch repair status, suggesting a possible role for E1317Q in colorectal tumorigenesis.
|
14578138 |
2003 |
|
rs17227424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Absence of the wild-type allele in tumors carrying the E530D variant suggests a possible role for this change in tumorigenesis.
|
14605947 |
2003 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the B-Raf activation segment mutations other than V599E reported in colorectal tumors do not necessarily contribute to carcinogenesis by increasing kinase and transforming activities.
|
14678966 |
2003 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the B-Raf activation segment mutations other than V599E reported in colorectal tumors do not necessarily contribute to carcinogenesis by increasing kinase and transforming activities.
|
14678966 |
2003 |
|
rs1799782
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The findings of the effect modification of the Arg(194)Trp on the relations of plasma alpha- and beta-carotene levels with breast cancer risk suggest a potential protective effect of carotenoids in breast carcinogenesis by preventing oxidative DNA damage.
|
14679022 |
2003 |
|
rs121913529
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed endogenous expression of KRAS(G12D) to progenitor cells of the mouse pancreas.
|
14706336 |
2003 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking.
|
15298955 |
2004 |