|
rs10036748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population.
|
27250029 |
2016 |
|
rs1018379423
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant.
|
22892241 |
2012 |
|
rs10254120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome.
|
23981578 |
2014 |
|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that SULT1A1 Arg213His polymorphism plays an important role in carcinogenesis, which may be a genetic factor affecting individual susceptibility to UADT cancer.
|
25225888 |
2014 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration.
|
23192612 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.
|
24326769 |
2014 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
So, as to find the association of p53Arg <sup>72</sup> Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic variant (rs1042522) was analyzed.
|
27614750 |
2016 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
|
rs1045485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As CASP10 and CASP8 functionally co-operate during apoptosis, we analysed the mutual effect of both CASP10 V410I and CASP8 D302H, resulting in a significant association between the number of the variant alleles I410 and H302 and a highly decreased familial BC risk (OR = 0.35, P(trend) = 0.007), pointing to the interaction between the CASP10 and CASP8 polymorphisms in breast carcinogenesis.
|
16251207 |
2006 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis.
|
24815441 |
2014 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to the carcinogenesis.
|
24070710 |
2013 |
|
rs1047840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that the SNPs of EXO1 K589E may contribute to cervical cancer carcinogenesis in Chinese populations.
|
22146767 |
2012 |
|
rs1048638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the haplotype of rs2071676, rs3829078, and rs1048638 combined has potential predictive significance in oral carcinogenesis.
|
23226559 |
2012 |
|
rs104893859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To better understand the role of Pitx2 on gonadotroph tumorigenesis and to explore new approach for inhibiting tumoral growth, the R91P mutant was transferred via a lentiviral vector in tumoral gonadotroph cells of two kinds: the αT3-1 cell line and human adenoma cells.
|
21810944 |
2011 |
|
rs104894230
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We demonstrated that transient transgenic expression of KRAS(G12V) in putative neural stem and/or progenitor cells induced brain tumorigenesis.
|
25644510 |
2015 |
|
rs104894230
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that TRAIL expression is consistently downregulated in HRAS(G12V)-transformed cells in stepwise tumorigenesis models derived from four different tissues due to DNA hypermethylation of CpG clusters within the TRAIL promoter.
|
21697397 |
2011 |
|
rs104894230
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Administration of a CXCL16-neutralizing antibody to KRAS(G12D) mice reduced activation of PI3K signaling to AKT and NF-κB, blocking carcinogenesis.
|
25683115 |
2015 |
|
rs104894230
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.
|
25902334 |
2015 |
|
rs1048943
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might play a role in lung carcinogenesis among non-smokers, possibly in combination with the GSTM1 null genotype.
|
12771031 |
2003 |
|
rs1048943
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database.
|
18463401 |
2008 |
|
rs1051740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two functional polymorphisms in the EPHX1 gene, Tyr113His and His139Arg can alter the enzyme activity, suggesting their possible association with carcinogenesis risk, particularly of some tobacco-related cancers.
|
21445251 |
2011 |