|
rs12826786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results demonstrate that the HOTAIR rs12826786 C>T polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here.
|
28342055 |
2017 |
|
rs132793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs2046210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, C6ORF97 showed significant worse prognostic values especially in luminal B subtype in the publically available data sets. rs2046210 and the upstream gene C6ORF97 might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients, which suggests that functional studies of this locus are imperative.
|
25370037 |
2015 |
|
rs2423279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis.
|
31849324 |
2019 |
|
rs29232
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, heterozygous deletion of the GSTM1 allele was associated with increased susceptibility to NPC, while an SNP in GABBR1 (rs29232, G>A) was associated with decreased risk, and might thus have a protective role on NPC carcinogenesis.
|
28881764 |
2017 |
|
rs4444235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis.
|
31849324 |
2019 |
|
rs7717457
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions</b>: SNP rs7717457 is associated with the selection of HBV BCP double mutations, providing an important clue to understanding the mechanisms of oncogenesis of HBV BCP double mutations.
|
31341412 |
2019 |
|
rs944289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis.
|
24815441 |
2014 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to the carcinogenesis.
|
24070710 |
2013 |
|
rs765189442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that the c.538G>A variation in ABCC11 does not contribute to breast carcinogenesis in women of European descent.
|
21655989 |
2011 |
|
rs17822931
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggest that the c.538G>A variation in ABCC11 does not contribute to breast carcinogenesis in women of European descent.
|
21655989 |
2011 |
|
rs17822931
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Because ABCC11, a member ABC transporter, is highly expressed in breast cancer tissue, it may be involved in the efflux of conjugated estrogen metabolites. rs17822931, a functional single nucleotide polymorphism (SNP) in ABCC11, may play a role in the carcinogenesis of breast cancer via estrogen.
|
30883634 |
2019 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study did not reveal an association of the AGT M235T polymorphism with oral oncogenesis, but certainly suggested a possible association of this specific polymorphism with other types of cancer.
|
18630525 |
2008 |
|
rs12774070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results implicate the interaction between ADAMTS14 gene polymorphisms and environmental mutagens as a risk factor of oral tumorigenesis and suggest a correlation of rs12774070 with the degree of oral tumor cell differentiation.
|
27463966 |
2016 |
|
rs61573157
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, our results suggest an involvement of ADAMTS14 SNP rs12774070 and rs61573157 in the liver tumorigenesis and implicate the ADAMTS14 gene polymorphism as a predict factor during the progression of HCC.
|
28231306 |
2017 |
|
rs1229984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Arg47His (rs1229984 G > A) in <i>ADH1B</i> have been frequently studied for its potential effect on carcinogenesis.
|
30872408 |
2019 |
|
rs1229984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail.
|
16332725 |
2006 |
|
rs1501299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the ADIPOQ rs1501299 may be a protective factor for carcinogenesis.
|
24720830 |
2014 |
|
rs1800625
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our data suggest a correlation of RAGE gene polymorphism rs1800625 with the early stage of liver tumorigenesis and implicate its protective role in the progression of HCC.
|
26313784 |
2015 |
|
rs1800625
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results indicate an involvement of RAGE SNP rs1800625 in the development of oral squamous cell carcinoma and implicate the interaction between RAGE gene polymorphisms and environmental mutagens as a predisposing factor of oral carcinogenesis.
|
25582438 |
2015 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings altogether demonstrate a significant association between RAGE gene rs1800624 polymorphism and breast cancer risk, and more importantly a cumulative impact of multiple risk associated polymorphisms in HMGB1/RAGE pathway on breast carcinogenesis.
|
27241711 |
2016 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study did not reveal an association of the AGT M235T polymorphism with oral oncogenesis, but certainly suggested a possible association of this specific polymorphism with other types of cancer.
|
18630525 |
2008 |
|
rs121434592
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To show the involvement of AKT1(E17K) directly in v-Abl-mediated tumorigenesis, we infected bone marrow cells from mice with bicistronic retroviruses encoding v-Abl and either wild-type or the mutant AKT1.
|
20440266 |
2010 |
|
rs121434592
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Moreover, SUMOylation loss dramatically reduced Akt1 E17K-mediated cell proliferation, cell migration, and tumorigenesis.
|
23884910 |
2013 |