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rs16906252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other SNPs associated with the risk of colon cancer (e.g., rs16906252 in MGMT) were found to affect mRNA expression levels in colon transverse and therefore working as possible cis-eQTL suggesting possible mechanisms of carcinogenesis.
|
31209889 |
2020 |
|
rs11646171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found looping chromatin interactions between non-coding regions at 6p25.3 (rs11646171) with the IRF4 promoter and at 8q24.21 (rs13254990) with the MYC promoter, both genes with strong relevance to B-cell tumorigenesis.
|
31102405 |
2019 |
|
rs119484086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One rare missense variant associated with the occurrence of prostate cancer (p.Arg781His) impairs the mitochondrial RNase Z activity of ELAC2, suggesting a functional link between tumorigenesis and mitochondrial RNA metabolism.
|
31045291 |
2019 |
|
rs121912660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs13254990
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found looping chromatin interactions between non-coding regions at 6p25.3 (rs11646171) with the IRF4 promoter and at 8q24.21 (rs13254990) with the MYC promoter, both genes with strong relevance to B-cell tumorigenesis.
|
31102405 |
2019 |
|
rs13428812
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis.
|
30867787 |
2019 |
|
rs1400826115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population.
|
30429230 |
2019 |
|
rs1453340173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We substituted Val285 with Ala (V285A) in an Ala-Val dipeptide, to mimic the conserved Ala-Ala in many members of the basic leucine-zipper family of transcription factors, important in gene regulation, cell proliferation and oncogenesis.
|
30566668 |
2019 |
|
rs17878467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
What's more, rs17878467 polymorphism may play a protect role in the tumorigenesis of urinary cancer, shown in heterozygote comparison model (MW vs. WW: OR = 0.882, 95% CI = 0.78-0.999, P = 0.048).
|
30463805 |
2019 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, although eNOS SNPs rs2070744 and rs1799983 do not display significant associations with cervical carcinogenesis and patient survival, cervical cancer patients with genotypes TC/CC in rs2070744 carry less risk of advanced stage, parametrium invasion and pelvic lymph node metastasis in Taiwan.
|
31258766 |
2019 |
|
rs2001389
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By integrating analysis on multiomics data, association studies and functional assays, we proposed that the common variant rs2001389 and the gene MFSD13A might be genetic modifiers of PC tumorigenesis.
|
31237042 |
2019 |
|
rs2070744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, although eNOS SNPs rs2070744 and rs1799983 do not display significant associations with cervical carcinogenesis and patient survival, cervical cancer patients with genotypes TC/CC in rs2070744 carry less risk of advanced stage, parametrium invasion and pelvic lymph node metastasis in Taiwan.
|
31258766 |
2019 |
|
rs2073859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As the mechanisms of LIMK-associated tumorigenesis are still unclear, we analyzed the tumorigenic functions of LIM kinase 2 (LIMK2) in human bladder cancer (BC) and explored whether the newly identified LIMK2 3´-UTR SNP rs2073859 (G-to-A allele) is correlated with clinical features.
|
30006972 |
2019 |
|
rs2276466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2276466 polymorphism might play different roles in carcinogenesis of various cancer types.
|
31040199 |
2019 |
|
rs2423279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis.
|
31849324 |
2019 |
|
rs2682818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Piles of evidence have supported the relationship between miR-618 rs2682818 polymorphism and tumorigenesis, but the conclusion remains inconsistent.
|
31383788 |
2019 |
|
rs3819102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C allele of rs3819102 is the risk allele for lung carcinogenesis in a dominant model (OR, 1.435; 95% CI, 1.188-1.735).
|
30180988 |
2019 |
|
rs4444235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis.
|
31849324 |
2019 |
|
rs5743836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric, and that TLR9 mRNA levels can be modulated by TLR9-1237 TC + CC variant genotypes and <i>H. pylori</i> infection.
|
31798780 |
2019 |
|
rs664589
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>In vitro</i> and <i>in vivo</i> experiments showed that the rs664589 C to G mutation facilitated carcinogenesis and metastasis of colorectal cancer.
|
31311811 |
2019 |
|
rs764803020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs7717457
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions</b>: SNP rs7717457 is associated with the selection of HBV BCP double mutations, providing an important clue to understanding the mechanisms of oncogenesis of HBV BCP double mutations.
|
31341412 |
2019 |
|
rs7726159
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the functional variant rs7726159 confers lung cancer susceptibility might by affecting MYC binding and inducing telomere lengthening, which provides a new insight into the crucial role of telomere biology in tumorigenesis.
|
30680798 |
2019 |
|
rs781490101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis.
|
30348990 |
2019 |
|
rs1057519853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas Q209L accounts for approximately half of GNAQ mutations in UM, Q209P is as frequent as Q209L and also promotes oncogenesis, but has not been characterized at the molecular level.
|
30352874 |
2018 |