|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In addition, our data indicate that rs22</span>94008 of PSCA is involved in GC susceptibility and confer its effect primarily in noncardia tumors (OR = 1.30, 95% CI 1.12-1.53, P < 10(-4)).
|
24146278 |
2014 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found that the T allele of rs2294008, an intronic variant of the PSCA gene at 8q24 that was previously associated with an increased risk of gastric cancer, was inversely associated with a decreased risk of ESCC (odds ratio = 0.90; 95% confidence interval, 0.81-0.99; P = 0.034).
|
24654646 |
2014 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Further, subgroup analysis based on ethnicity suggested MUC1 rs4072037 polymorphism had a subtly reduced cancer risk among Asian population, and stratified analysis by cancer types showed significantly decreased risk of gastric cancer in all genetic models.
|
24755768 |
2014 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95% confidence interval (CI) = 0.67-0.91 for AG vs AA].
|
24254309 |
2014 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population.
|
24254309 |
2014 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We analyzed 3 SNPs in the PSCA gene (rs2294008, rs9297976 and rs12155758) which were previously found to be associated with GC risk in Europeans.
|
24023815 |
2013 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The G allele of MUC1 rs4072037 was significantly associated with a decreased risk of GC (OR = 0.72, 95 % CI 0.68-0.77; P = 7.82 × 10(-25)), as compared with A allele.
|
24072653 |
2013 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium.
|
22426141 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously.
|
22387998 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
|
22481254 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Association of the PSCA rs2294008 C>T polymorphism with gastric cancer risk: evidence from a meta-analysis.
|
22938475 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results confirm the association between variation in the promoter region of PSCA and GC risk in Caucasians and also indicate that the rs2294</span>008 variant is a similar risk factor for both the diffuse and intestinal-types of GC.
|
21681742 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.
|
22938426 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Although modest limitations and potential bias cannot be eliminated, this meta-analysis suggests that PSCA -rs2294008C>T and -rs2976392G>A are potential factors of GC development for Eastern Asians, and future work may incorporate these findings and evaluate these variants as potential markers for screening and early diagnosis of GC.
|
22155405 |
2012 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings for rs4072037 and the risk of GC are in agreement with one previous report for a Caucasian population.
|
22805490 |
2012 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model.
|
22938415 |
2012 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
|
21070776 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study showed that rs2294008 in the PSCA gene was associated with increased risks of gastric cancer in a Korean population, suggests that rs2294008 might play an important role in gastric carcinogenesis.
|
21538581 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
If validated in further studies, PSCA rs2294008</span> could be useful marker of sur</span>vival assessment and individualized clinical therapy for gastric cancer, particularly among the diffuse-type gastric cancer.
|
21064099 |
2011 |
|
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, The T allele of PSCA rs2294008 is associated with increased risk of gastric cancer, especially intestinal type, poorly differentiated, early onset, and noncardia gastric cancer in Chinese population.
|
21268123 |
2011 |
|
rs4072037
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found that rs4072037 at 1q22 and rs2274223 at 10q23 were significantly associated with risk of GC with per allele odds ratio (OR) of 0.72 [95% confidence interval (CI): 0.63-0.81; P = 2.98 × 10(-7)] and 1.42 (95% CI: 1.27-1.58; P = 9.68 × 10(-10)), respectively.
|
21427165 |
2011 |