|
rs11896604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under additive model and recessive model, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 also activated the risk of GC (P < 0.05).
|
28415712 |
2017 |
|
rs6713088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the minor alleles of rs6713088, rs11125529, rs12615793, rs843711, rs11896604, rs843706 and rs17045754 significantly stimulated the risk of GC, and homozygous alleles of above SNPs except rs6713088 were also found increasing the GC risk (P < 0.05).
|
28415712 |
2017 |
|
rs17045754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under additive model and recessive model, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 also activated the risk of GC (P < 0.05).
|
28415712 |
2017 |
|
rs843706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further results of haplotype analysis founds that the haplotypes "TTCTAATG" (rs1682111, rs843752, rs10439478, rs843645, rs11125529, rs12615793, rs843711, and rs11896604) and "AC" (rs843706 and rs17045754) were more frequency among patients with GC, on the contrary, the haplotypes "CG" had a protective role in the GC risk (P < 0.05).
|
28415712 |
2017 |
|
rs4963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, a missense variant at the codon of ADD1's phosphorylation site, rs4963 (Ser586Cys), was reported to modify the risk of non-cardia gastric cancer.
|
25816007 |
2015 |
|
rs1229984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk.
|
22144473 |
2012 |
|
rs1229984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no significant relationship was measured between ADH1B Arg47His and gastric cancer risk.
|
28002588 |
2016 |
|
rs17033
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype and allele frequency analysis of these SNPs revealed that G allele of rs17033 is a risk allele (A vs G: OR = 3.67, 95% CI = 1.54-8.75, p = 0.002) for GC.
|
29166882 |
2017 |
|
rs283411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (OR(T v C) = 0.59; 95% CI = 0.38-0.91 and OR(T v C) = 1.34; 95% CI = 1.00-1.79, respectively).
|
22144473 |
2012 |
|
rs266729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, for those patients without a previous history of alcohol drinking, the rs266729 GG/CG genotype carriers showed a significantly decreased gastric cancer mortality compared to homogeneity CC patients (HR 0.74, 95 % CI 0.56-0.97; p = 0.032) after adjustment for variants age, sex, smoking status, tumor stage, tumor location and post-surgery chemotherapy.
|
25270251 |
2015 |
|
rs822395
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients.
|
25270251 |
2015 |
|
rs12733285
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients.
|
25270251 |
2015 |
|
rs1342387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients.
|
25270251 |
2015 |
|
rs184003
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In contrast, the rs184003 GT genotype represented significantly reduced risk for gastric cancer (adjusted OR 0.62, 95% CI 0.39-0.99).
|
28184178 |
2017 |
|
rs184003
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b><i>RAGE</i> gene SNP rs1800625 was significantly associated with gastric cancer risk, and rs1800625 and rs184003 were related to tumor clinical stage, indicating that <i>RAGE</i> gene may be a gastric cancer-susceptibility gene.
|
30719146 |
2019 |
|
rs2070600
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genetic variant Gly82Ser of RAGE influences its function and is associated with an increased risk of gastric cancer and multiple sclerosis.
|
24248547 |
2014 |
|
rs2070600
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings indicate that the RAGE Gly82Ser polymorphism may confer not only an increased risk of gastric cancer but also with invasion of gastric cancer in the Chinese population.
|
18519797 |
2008 |
|
rs1800625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b><i>RAGE</i> gene SNP rs1800625 was significantly associated with gastric cancer risk, and rs1800625 and rs184003 were related to tumor clinical stage, indicating that <i>RAGE</i> gene may be a gastric cancer-susceptibility gene.
|
30719146 |
2019 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the present study was to clarify the association between the AGT M235T polymorphism and gastric cancer.
|
21584499 |
2011 |
|
rs1130233
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MTOR rs1064261and AKT rs1130233 polymorphisms were associated with increased GC risk in males and increased AG risk in H. pylori-negative individuals.
|
26317520 |
2015 |
|
rs2494752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the potentially functional AKT1 rs2494752 SNP may affect GCa susceptibility, likely by modulating the AKT1 promoter transcriptional activity.
|
26818920 |
2016 |
|
rs671
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer.
|
23455379 |
2013 |
|
rs671
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10<sup>-8</sup>), rs10052657 in PDE4D at 5q11.2 (per C allele: OR = 1.12, 95% CI: 1.01-1.25, P = 3.28 × 10<sup>-2</sup>) and rs671 in ALDH2 at 12q24.12 (per A-allele: OR = 0.83, 95% CI: 0.75-0.91, P = 1.14 × 10<sup>-4</sup>) were significantly associated with GC risk.
|
30202044 |
2018 |
|
rs671
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggested that ALDH2 genetic polymorphisms might be strongly correlated with an increased risk of gastric cancer (allele model: OR = 1.21, 95%CI: 1.11 ∼ 1.32, P<0.001; dominant model: OR = 1.23, 95%CI: 1.09 ∼ 1.39, P = 0.001; respectively), especially for rs671 polymorphism.
|
24633362 |
2014 |
|
rs671
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In conclusion, rs17033 of ADH1B and rs671 of ALDH2 SNPs were associated with GC risk and smoking habit may further modify the effect of rs671.
|
29166882 |
2017 |