|
rs765693356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs767197560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, NRG1-positive HNSCC cell lines that secreted high levels of AREG and TGFα or contained high levels of EGFR homodimers (H11D) demonstrated a better response to KTN3379.
|
28723928 |
2017 |
|
rs768388223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs770029196
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, NRG1-positive HNSCC cell lines that secreted high levels of AREG and TGFα or contained high levels of EGFR homodimers (H11D) demonstrated a better response to KTN3379.
|
28723928 |
2017 |
|
rs773016917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation.
|
26918827 |
2017 |
|
rs7834169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An upstream variant of MIR548H4 (rs7834169), replicated its association with overall HNSCC risk as well as risk of oral cavity cancer.
|
28582492 |
2017 |
|
rs12452890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We sought to determine whether there was a difference in the frequency of single nucleotide polymorphisms (SNPs) in EVER1 (rs2613516, rs12449858) and EVER2 (rs7205422, rs12452890) between HNSCC patients with HPV-positive and HPV-negative tumors, and healthy controls.
|
27097911 |
2016 |
|
rs139994842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the NOTCH1 gene rs139994842 that shares linkage with SMs is associated with HNSCC risk (OR = 3.46), increasing when SMs in NOTCH1 are involved (OR = 7.74), and furthermore when there are SMs in conjunction to betel quid chewing (OR = 32.11), which is a related independent environmental risk factor after adjusting for substances use (alcohol, betel quid, cigarettes) and age.
|
27035284 |
2016 |
|
rs180127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This pilot study provides preliminary evidence supporting genetic variation of EGFR (rs2227983), KRAS (rs61764370) and FCGR2A (rs180127) as useful biomarkers for predicting reduced skin toxicity in HNSCC patients treated with a cetuximab-based therapy.
|
27938998 |
2016 |
|
rs20417
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC.
|
27412115 |
2016 |
|
rs2736100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, among seven selected SNPs, only G allele of rs2736100 related to RTL in Caucasians was significantly associated with both the decreased RTL (P = 0.002) and the increased susceptibility to SCCHN in Chinese (additive model: adjusted OR = 1.17, 95%CI = 1.00-1.38, P = 0.049).
|
26857734 |
2016 |
|
rs4919510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant association was detected between the other three SNPs (miR-149 rs2292832, miR-146a rs2910164, and miR-608 rs4919510) and HNSCC risk.
|
27515039 |
2016 |
|
rs5275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC.
|
27412115 |
2016 |
|
rs7213430
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggested that SNP rs7213430 in the 3'-UTR of BRIP1 might contribute to SCCHN susceptibility by affecting the binding activity of miR-101 and resulting in a decreased BRIP1 expression.
|
26711789 |
2016 |
|
rs8136867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analyses between the 800 candidate SNPs (covering 82 genes) and pain in a patient cohort of 1368 patients with HNSCC (206 patients with severe pain vs. 1162 with non-severe pain) showed the highest significance for MAPK1/ERK2, a gene belonging to the MAP kinase family (rs8136867, p value = 8.92 × 10(-4); odds ratio [OR] = 1.33, 95 % confidence interval [CI]: 1.13-1.58).
|
26872611 |
2016 |
|
rs1049430
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, our data demonstrate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3GL2 and could be used as a prognostic marker of HNSCC.
|
25728707 |
2015 |
|
rs1389500636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The HNSCC cells with MAPK1 E322K exhibited enhanced EGFR phosphorylation and erlotinib sensitivity compared with wild-type MAPK1 cells.
|
26181029 |
2015 |
|
rs2072454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
EGFR intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05).
|
25511740 |
2015 |
|
rs2228001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC).
|
26505394 |
2015 |
|
rs2498804
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP of rs2498804 can recognize patients resistant to RT-CT. Further studies are needed to confirm our data and to investigate the role of Akt SNPs in HNSCC patients.
|
25550560 |
2015 |
|
rs3813867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADH1B histidine allele (rs1229984), CYP2E1 rs3813867 heterozygous genotype, and GSTT1 deletion conferred protection against HNSCC (OR: 0.318 [0.04-0.75], OR: 0.13 [0.02-0.94], and OR: 0.12 [0.02-0.60], respectively) while GSTP1 (rs1695) Val/Val genotype was related to an increased risk (OR: 4.12 [1.11-15.31]).
|
25639971 |
2015 |
|
rs6970262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users.
|
25511740 |
2015 |
|
rs7208422
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we have tested the hypothesis that the common TMC8 SNP rs7208422 is associated with high-risk HPV infection and risk of head and neck squamous cell carcinoma (HNSCC).
|
25853559 |
2015 |
|
rs845561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users.
|
25511740 |
2015 |
|
rs1056836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.
|
24343338 |
2014 |