|
rs6983267
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The combination of rs6983267 on 8q24.21 and rs9929218 on 16q22.2 was associated with a history of colorectal adenoma (carriers of GG and AA, respectively; OR, 2.28; 95% CI, 1.32-3.93; P = 5.0 x 10(-4)).
|
20638935 |
2010 |
|
rs6983267
|
|
|
0.760 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the 8q24.21-rs6983267 polymorphism is associated with CRC/CRA susceptibility, but these associations vary in different ethnic populations.
|
24375194 |
2014 |
|
rs6983267
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In conclusion, some variants associated with CRC risk (rs10505477, rs6983267, rs10795668 and rs11255841) are also involved in the susceptibility to CRA and specific subtypes.
|
30194776 |
2019 |
|
rs6983267
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Three polymorphic sites at chromosome 8q24 (rs7837328, rs10808555, rs6983267) have been associated with risk for colorectal adenomas.
|
23776012 |
2014 |
|
rs6983267
|
|
|
0.760 |
GeneticVariation |
BEFREE |
There was a statistically significant direct association of rs6983267 with colorectal adenoma that was consistent with those in previous reports.
|
24115145 |
2014 |
|
rs6983267
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We found no significant differences between the association of rs6983267 and colorectal cancer and colorectal adenomas.
|
21455501 |
2011 |
|
rs11255841
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In conclusion, some variants associated with CRC risk (rs10505477, rs6983267, rs10795668 and rs11255841) are also involved in the susceptibility to CRA and specific subtypes.
|
30194776 |
2019 |
|
rs16892766
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs16892766-C allele might be risk-conferring factors for the development of CRC, but not for CRA.
|
25293934 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No evidence of association of C677T (4,616 patients and 6,338 controls) and A1298C (1,272 patients and 1,684 controls) with colorectal adenoma were found.
|
17089070 |
2007 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).
|
16783607 |
2006 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither MTHFR C677T nor ALDH2 showed a measurable association with colorectal adenoma.
|
16108833 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.
|
10919734 |
2000 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, there were no clear interactions of the ADH1B with ALDH2 Glu487Lys and MTHFR C677T with regard to the risk of colorectal adenoma.
|
21517275 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk.
|
18322814 |
2008 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was observed between MTHFR C677T genotype and colorectal adenomas.
|
15941973 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas.
|
12690011 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States).
|
15286469 |
2004 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status.
|
17087956 |
2006 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Almost all of seven studies of colorectal adenoma have found no association between C677T polymorphism and adenoma, but the 677TT genotype seems to be related to increased risk when folate status is poor.
|
16128738 |
2005 |
|
rs1801166
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The APC Variant p.Glu1317Gln predisposes to colorectal adenomas by a novel mechanism of relaxing the target for tumorigenic somatic APC mutations.
|
19701947 |
2009 |
|
rs1801166
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The APC I1307K and E1317Q variants predispose to colorectal adenomas and carcinomas in Caucasians, but data are lacking in Asians.
|
15266213 |
2005 |
|
rs1801166
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The APC E1317Q variant is associated with colorectal neoplasia, particularly colorectal adenomas, but further studies are still needed.
|
19474113 |
2009 |
|
rs1801166
|
|
|
0.050 |
GeneticVariation |
BEFREE |
E1317Q is significantly associated with multiple colorectal adenomas (OR = 11.
|
11001924 |
2000 |
|
rs1801166
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, our results confirm that only a very small fraction of colorectal adenomas</span> may be associated with the presence of E1317Q.
|
12537656 |
2002 |
|
rs1805087
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The GG genotype of MTR A2756G was associated with an increased risk of colorectal adenomas; odds ratios for AG and GG versus AA genotype were 0.99 (95% confidence interval 0.78-1.26) and 1.72 (1.04-2.82), respectively.
|
22407825 |
2012 |