Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801166
rs1801166
APC
0.050 GeneticVariation BEFREE E1317Q is significantly associated with multiple colorectal adenomas (OR = 11. 11001924

2000
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk. 18322814

2008
dbSNP: rs1042028
rs1042028
SULT1A1
0.010 GeneticVariation BEFREE A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and might thus modify the association between smoking and colorectal adenomas. 14618622

2004
dbSNP: rs370302501
rs370302501
NAT1
0.010 GeneticVariation BEFREE A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and might thus modify the association between smoking and colorectal adenomas. 14618622

2004
dbSNP: rs9282861
rs9282861
SULT1A1
0.010 GeneticVariation BEFREE A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and might thus modify the association between smoking and colorectal adenomas. 14618622

2004
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Almost all of seven studies of colorectal adenoma have found no association between C677T polymorphism and adenoma, but the 677TT genotype seems to be related to increased risk when folate status is poor. 16128738

2005
dbSNP: rs1319831679
rs1319831679
NQO1
0.010 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg</span>, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs2234922
rs2234922
EPHX1
0.010 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg</span>, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs1695
rs1695
GSTP1
0.020 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs1138272
rs1138272
GSTP1
0.010 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs1258159645
rs1258159645
NQO1
0.020 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs1800566
rs1800566
NQO1
0.020 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs1346600942
rs1346600942
EPHX1
0.010 GeneticVariation BEFREE Although with modest limitations and biases, this metaanalysis suggests that EPHX1 Tyr113His and His139Arg, GSTT1, GSTM1, GSTP1 Ile105Val and Ala114Val polymorphisms may be not risk factors for CRA development, while Ser allele of NQO1 Ser187 Pro may be a modest risk factor for CRA development, and may be used with other genetic markers for screening CRA in the future. 22161138

2012
dbSNP: rs1800975
rs1800975
XPA
0.010 GeneticVariation BEFREE An interaction between bulky DNA adduct levels and XPA rs1800975 on prevalence of colorectal adenoma was observed. 29871536

2018
dbSNP: rs11766140
rs11766140 		0.700 GeneticVariation GWASCAT Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. 29228715

2017
dbSNP: rs34548439
rs34548439
OSMR-AS1
0.700 GeneticVariation GWASCAT Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. 29228715

2017
dbSNP: rs35226739
rs35226739
GRM7
0.700 GeneticVariation GWASCAT Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. 29228715

2017
dbSNP: rs6068583
rs6068583
LOC101927770
0.700 GeneticVariation GWASCAT Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. 29228715

2017
dbSNP: rs7944251
rs7944251
FAT3
0.700 GeneticVariation GWASCAT Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. 29228715

2017
dbSNP: rs7229639
rs7229639
SMAD7
0.010 GeneticVariation BEFREE Besides, seven SNPs (rs10808555, rs7014346, rs7837328, rs704017, rs11196172, rs4779584, and rs7229639) were significantly associated with CRC, and another one SNP rs11903757 was over-represented in CRA compared with controls. 27769063

2016
dbSNP: rs11903757
rs11903757 		0.010 GeneticVariation BEFREE Besides, seven SNPs (rs10808555, rs7014346, rs7837328, rs704017, rs11196172, rs4779584, and rs7229639) were significantly associated with CRC, and another one SNP rs11903757 was over-represented in CRA compared with controls. 27769063

2016
dbSNP: rs6983267
rs6983267
POU5F1B ; CASC8 ; PCAT1 ; CCAT2
G 0.760 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241

2019
dbSNP: rs11255841
rs11255841 		T 0.710 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241

2019
dbSNP: rs16892766
rs16892766 		C 0.710 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241

2019
dbSNP: rs10049390
rs10049390
SLCO2A1
A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241

2019