Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs368087026
rs368087026
SLC19A1
0.010 GeneticVariation BEFREE The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. 24241962

2013
dbSNP: rs4149056
rs4149056
SLCO1B1
0.010 GeneticVariation BEFREE Patients with OATP1B1 521T>C mutant-type carrier had slightly higher trough SDC (0.98 ± 0.53 ng/mL) than those with wild-type carrier (0.74 ± 0.40 ng/mL) when they have repaired renal function.Heart failure patients with severe renal dysfunction (GFR<60 mL/min) and/or OATP1B1 521T>C mutant-type carriers are recommended a smaller dosage of digoxin and strict therapeutic drug monitoring. 30946364

2019
dbSNP: rs538166970
rs538166970
ACE
0.010 GeneticVariation BEFREE In contrast, another mutant, R1180P, was compatible with life after transient neonatal renal insufficiency. 24163131

2014
dbSNP: rs61747728
rs61747728
NPHS2
0.010 GeneticVariation BEFREE The early demonstration of R229Q in individuals with TBMN may indicate those at increased risk of proteinuria and renal impairment. 18726620

2008
dbSNP: rs696217
rs696217
GHRL ; GHRLOS
0.010 GeneticVariation BEFREE The Leu72Met polymorphism was also associated with serum total cholesterol levels in diabetic nephropathy patients with renal</span> dysfunction; the 72Met carriers had lower total cholesterol levels than the 72Met non-carriers (P < 0.05). 16793966

2006
dbSNP: rs7222094
rs7222094
MAP3K14
0.010 GeneticVariation BEFREE Patients having the CC genotype of rs7222094 in SPH experienced more renal and hematological dysfunction (p = 0.003 and p = 0.011), while patients of the VASST cohort with the rs7222094 CC genotype showed the same trend toward more renal dysfunction. 21257964

2011
dbSNP: rs738409
rs738409
PNPLA3
0.010 GeneticVariation BEFREE The patatin-like phospholipase 3 (PNPLA3) polymorphism rs738409 (c.444C>G) is associated with the risk of NAFLD and/or renal dysfunction; however, the influence of the weight status on the associations remains unknown. 26200108

2015
dbSNP: rs74315289
rs74315289
BSND
0.010 GeneticVariation BEFREE Renal dysfunction and barttin expression in Bartter syndrome Type IV associated with a G47R mutation in BSND in a family. 21269598

2011
dbSNP: rs7456421
rs7456421
HIPK2
0.010 GeneticVariation BEFREE No statistical significance of allele transfer was found, which means that there were no associations between rs7456421 and rs 2030712 SNPs of HIPK2 gene and the incidence of renal dysfunction. 23540226

2013
dbSNP: rs7493
rs7493
PON2
0.010 GeneticVariation BEFREE We examined the relationship between variation at the C311S and A148G polymorphisms (together with PON2 intronic variant rs12704795) and indices of renal dysfunction (progression to micro- and macroalbuminuria, plasma creatinine increases) in 3,374 newly diagnosed type 2 diabetic subjects from the UK Prospective Diabetes Study followed prospectively (median 14.0 years), using proportional hazards models, adjusted for sex, ethnicity and other known or putative risk factors. 17096118

2006
dbSNP: rs7582694
rs7582694
STAT4
0.010 GeneticVariation BEFREE In the case-only meta-analysis of the two cohorts, the STAT4 SNP rs7582694 was associated with severe renal insufficiency with p = 1.6 × 10(-3) and OR 2.22. 24386384

2013
dbSNP: rs777919630
rs777919630
CBS
0.010 GeneticVariation BEFREE We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine beta-synthase (CBS) 844ins68 polymorphisms, and homocysteine levels before and after methionine (100 mg/kg) loading in 58 patients with angiographically documented renal artery stenosis and mildly impaired renal function. 11918280

2001
dbSNP: rs867394500
rs867394500
ACE
0.010 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003
dbSNP: rs118203478
rs118203478
TSC1
CA 0.700 CausalMutation CLINVAR

dbSNP: rs137852832
rs137852832
CEP290
A 0.700 CausalMutation CLINVAR

dbSNP: rs137852834
rs137852834
CEP290
A 0.700 CausalMutation CLINVAR

dbSNP: rs1553948516
rs1553948516
SCARB2
TG 0.700 CausalMutation CLINVAR

dbSNP: rs1555487316
rs1555487316
UMOD
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1567202189
rs1567202189
PKD1
CGTG 0.700 GeneticVariation CLINVAR

dbSNP: rs1569492161
rs1569492161
COL4A5
C 0.700 CausalMutation CLINVAR

dbSNP: rs530391015
rs530391015
INF2
A 0.700 GeneticVariation CLINVAR

dbSNP: rs771454167
rs771454167
CEP290
A 0.700 CausalMutation CLINVAR

dbSNP: rs886039813
rs886039813
OFD1
G 0.700 CausalMutation CLINVAR