Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs867394500
rs867394500
ACE
0.010 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003
dbSNP: rs777919630
rs777919630
CBS
0.010 GeneticVariation BEFREE We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine beta-synthase (CBS) 844ins68 polymorphisms, and homocysteine levels before and after methionine (100 mg/kg) loading in 58 patients with angiographically documented renal artery stenosis and mildly impaired renal function. 11918280

2001
dbSNP: rs1800470
rs1800470
TGFB1
0.010 GeneticVariation BEFREE To determine whether genetic factors are involved in the development of renal dysfunction due to cyclosporine nephrotoxicity, we analyzed 2 polymorphisms in the signal sequence of the transforming growth factor (TGF)-beta 1 gene; codon 10 (Leu(10) --> Pro) and codon 25 (Arg(25) --> Pro). 11008076

2000
dbSNP: rs1800471
rs1800471
TGFB1
0.020 GeneticVariation BEFREE Secondly, we performed a case-control orientated study to determine whether rs1800471 polymorphism and other factors influence the progression of renal impairment. 25298263

2015
dbSNP: rs28933979
rs28933979
TTR
0.020 GeneticVariation BEFREE ATTR-V30M patients with FNEs had longer disease duration (OR=1.24; 95% CI 1.07 to 1.43), renal dysfunction (OR=4.65; 95% CI 1.20 to 18.05) and were men (OR=3.57; 95% CI 1.02 to 12.30). 25091367

2015
dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE We analyzed single nucleotide polymorphisms (SNPs) associated with cardiovascular pathophysiology (including AGT1R T573C, AGT1R A1166C, and AGT M235T) and presence of renal dysfunction (eGFR<60 ml/min/1.73 m2) or history of CHD. 19327134

2009
dbSNP: rs28933979
rs28933979
TTR
0.020 GeneticVariation BEFREE Renal manifestations of ATTR V30M, like other amyloidoses, are different levels of proteinuria and renal insufficiency. 12832749

2003
dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. 12832734

2003
dbSNP: rs1800471
rs1800471
TGFB1
0.020 GeneticVariation BEFREE To determine whether genetic factors are involved in the development of renal dysfunction due to cyclosporine nephrotoxicity, we analyzed 2 polymorphisms in the signal sequence of the transforming growth factor (TGF)-beta 1 gene; codon 10 (Leu(10) --> Pro) and codon 25 (Arg(25) --> Pro). 11008076

2000
dbSNP: rs1217691063
rs1217691063
MTHFR
0.040 GeneticVariation BEFREE The T allele at MTHFR C677T was the risk factor for prolonged high MTX concentration (p = 0.009, OR 5.54, 95 % CI 1.54-19.85), but not for renal dysfunction. 24241962

2013
dbSNP: rs1217691063
rs1217691063
MTHFR
0.040 GeneticVariation BEFREE The MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients. 23846111

2013
dbSNP: rs1217691063
rs1217691063
MTHFR
0.040 GeneticVariation BEFREE Sign of these predictive effects is opposite: subjects with MTHFR 677C>T polymorphism have lower likelihood of renal insufficiency; differently, wild-type MTHFR genotype subjects have lower GFR and greater hsCRP, iPTH, RRI, and LVH. 23534584

2013
dbSNP: rs1217691063
rs1217691063
MTHFR
0.040 GeneticVariation BEFREE We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine beta-synthase (CBS) 844ins68 polymorphisms, and homocysteine levels before and after methionine (100 mg/kg) loading in 58 patients with angiographically documented renal artery stenosis and mildly impaired renal function. 11918280

2001
dbSNP: rs118203478
rs118203478
TSC1
CA 0.700 CausalMutation CLINVAR

dbSNP: rs137852832
rs137852832
CEP290
A 0.700 CausalMutation CLINVAR

dbSNP: rs137852834
rs137852834
CEP290
A 0.700 CausalMutation CLINVAR

dbSNP: rs1553948516
rs1553948516
SCARB2
TG 0.700 CausalMutation CLINVAR

dbSNP: rs1555487316
rs1555487316
UMOD
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1567202189
rs1567202189
PKD1
CGTG 0.700 GeneticVariation CLINVAR

dbSNP: rs1569492161
rs1569492161
COL4A5
C 0.700 CausalMutation CLINVAR

dbSNP: rs530391015
rs530391015
INF2
A 0.700 GeneticVariation CLINVAR

dbSNP: rs771454167
rs771454167
CEP290
A 0.700 CausalMutation CLINVAR

dbSNP: rs886039813
rs886039813
OFD1
G 0.700 CausalMutation CLINVAR