HDAC5, histone deacetylase 5, 10014

N. diseases: 114; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.020 Biomarker group LHGDN Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. 15194749 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.500 Biomarker disease PSYGENET Furthermore, viral-mediated HDAC5 overexpression in the hippocampus blocked imipramine's ability to reverse depression-like behavior. 16501568 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET Furthermore, viral-mediated HDAC5 overexpression in the hippocampus blocked imipramine's ability to reverse depression-like behavior. 16501568 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.320 Biomarker disease PSYGENET Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.320 AlteredExpression disease BEFREE Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 AlteredExpression disease BEFREE Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Therapeutic disease CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C0001546
Disease: Adjustment Disorders
Adjustment Disorders 		0.300 Biomarker group CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C0011579
Disease: Reactive depression
Reactive depression 		0.300 Biomarker disease CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Therapeutic group CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C1522512
Disease: Transient Situational Disturbance
Transient Situational Disturbance 		0.300 Biomarker disease CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C0018801
Disease: Heart failure
Heart failure 		0.020 Biomarker disease BEFREE Moreover, adenovirus-mediated overexpression of PKD, CaMKIIdelta(B), or CaMKIIdelta(C) reduced baseline HDAC5 F(nuc)/F(cyto) in control myocytes (3.4+/-0.5, 3.8+/-0.5, and 5.2+/-0.5, respectively), approaching that seen in HF. 18218981 2008
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.020 Biomarker disease BEFREE Moreover, adenovirus-mediated overexpression of PKD, CaMKIIdelta(B), or CaMKIIdelta(C) reduced baseline HDAC5 F(nuc)/F(cyto) in control myocytes (3.4+/-0.5, 3.8+/-0.5, and 5.2+/-0.5, respectively), approaching that seen in HF. 18218981 2008
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.200 Biomarker disease RGD A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. 18937310 2008
CUI: C0005938
Disease: Bone Density
Bone Density 		0.100 GeneticVariation phenotype GWASDB Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. 19801982 2009
CUI: C0005938
Disease: Bone Density
Bone Density 		0.100 GeneticVariation phenotype GWASCAT Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. 19801982 2009
CUI: C0410438
Disease: Primary osteoporosis
Primary osteoporosis 		0.010 Biomarker disease BEFREE A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. 19920351 2009
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 Biomarker disease BEFREE Taken together, our results reveal that phosphorylation-dependent derepression of HDAC5 mediates flow-induced KLF2 and eNOS expression as well as flow anti-inflammation, and suggest that HDAC5 could be a potential therapeutic target for the prevention of atherosclerosis. 20042720 2010
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 Biomarker disease BEFREE Taken together, our results reveal that phosphorylation-dependent derepression of HDAC5 mediates flow-induced KLF2 and eNOS expression as well as flow anti-inflammation, and suggest that HDAC5 could be a potential therapeutic target for the prevention of atherosclerosis. 20042720 2010
CUI: C3887499
Disease: Renal cyst
Renal cyst 		0.010 Biomarker phenotype BEFREE Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. 20181743 2010
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.010 Biomarker disease BEFREE In addition, we conducted functional studies using siRNA-mediated knockdown of HDAC5 and HDAC9 in medulloblastoma cells. 20413433 2010
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma 		0.010 Biomarker disease BEFREE In addition, we conducted functional studies using siRNA-mediated knockdown of HDAC5 and HDAC9 in medulloblastoma cells. 20413433 2010
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.010 Biomarker disease BEFREE In addition, we conducted functional studies using siRNA-mediated knockdown of HDAC5 and HDAC9 in medulloblastoma cells. 20413433 2010