|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dexmedetomidine attenuates the toxicity of β‑amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5.
|
30483749 |
2019 |
|
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05).
|
31001930 |
2019 |
|
Carcinoma, Transitional Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We conclude that overexpression of HDAC5 may generally decrease proliferation in UC, but, intriguingly, may induce EMT on its own in certain circumstances.
|
31052182 |
2019 |
|
Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
βOHB attenuates cisplatin-induced apoptosis by activation of HDAC5 in HRCE cells, suggesting that βOHB may be a new therapeutic agent for cisplatin nephropathy.
|
30851335 |
2019 |
|
Mycoplasma Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation.
|
30738045 |
2019 |
|
Mycoplasma pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We report here that HDAC5 expression is decreased in peripheral blood mononuclear cells (PBMCs) from Mycoplasma pneumoniae pneumonia (MPP) children as well as in MP-infected peritoneal and THP-1 macrophages.
|
30738045 |
2019 |
|
Septicemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Our findings revealed that AMPK activation-mediated HDAC5 phosphorylation and KLF2 restoration is, at least partially, responsible to the anti-inflammatory effects of metformin in endotoxemia-induced endothelial cells, which has important implications for the future development of interfering therapies of sepsis.
|
31002870 |
2019 |
|
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone proteins and a heightened HDAC activation, notably of HDAC5, is associated with vascular disorders, such as atherosclerosis.
|
30793765 |
2019 |
|
Polycystic Kidney, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that HDAC5 nucleocytoplasmic shuttling may be modulated to impede disease progression in ADPKD and uncovers an unexpected role for a class of dopamine receptors in renal epithelial morphogenesis.
|
31059522 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05).
|
31001930 |
2019 |
|
Inflammatory pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.
|
31255170 |
2019 |
|
Sepsis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Our findings revealed that AMPK activation-mediated HDAC5 phosphorylation and KLF2 restoration is, at least partially, responsible to the anti-inflammatory effects of metformin in endotoxemia-induced endothelial cells, which has important implications for the future development of interfering therapies of sepsis.
|
31002870 |
2019 |
|
Hyperplastic Polyp
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histone deacetylase 5 (HDAC5) is involved in the regulation of inflammation, however, whether it associates with immunity against MP infection is not determined.
|
30738045 |
2019 |
|
Endotoxemia
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Our findings revealed that AMPK activation-mediated HDAC5 phosphorylation and KLF2 restoration is, at least partially, responsible to the anti-inflammatory effects of metformin in endotoxemia-induced endothelial cells, which has important implications for the future development of interfering therapies of sepsis.
|
31002870 |
2019 |
|
social stress
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interactions between housing conditions and social stress were seen only for HDAC5 expression, which showed a further increase in the isolated + CUS group but remained constant in accompanied animals.
|
30880220 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, network‑based meta‑analysis confirmed growth factor receptor‑bound protein 2 and histone deacetylase 5 as pivotal hub genes in PDAC compared with normal tissue.
|
31257501 |
2019 |
|
Urothelial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We conclude that overexpression of HDAC5 may generally decrease proliferation in UC, but, intriguingly, may induce EMT on its own in certain circumstances.
|
31052182 |
2019 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, HDAC3 inhibitors and HDAC5 nuclear boosters show protection from tachypacing-induced changes and therefore may represent interesting therapeutic options in clinical AF.
|
30321539 |
2018 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, in hISMC from resected Crohn's strictures, we observed a significantly reduced contractile phenotype compared with patient-matched intrinsic controls that was associated with increased patient-specific expression of DNA methyltransferase 1, HDAC2, and HDAC5.
|
30110565 |
2018 |
|
Fatty Liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Most important, hepatic overexpression of a phosphorylation-deficient mutant HDAC5 2SA promotes hepatic fatty acid oxidation gene expression and protects against hepatic steatosis in mice fed a high-fat diet.
|
29229738 |
2018 |
|
Neuralgia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, interventions that reduce HDAC5/SOX10 expression may represent promising avenues in the treatment of neuropathic pain.
|
29447134 |
2018 |
|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis.
|
29339432 |
2018 |
|
Alveolar rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PAX3-FOXO1 also regulates histone deacetylase 5 (HDAC5) in ARMS cells, and results of RNA interference studies confirmed that PAX3-FOXO1-mediated repression of IL24 is HDAC5-dependent.
|
30190424 |
2018 |
|
Cardiomyopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our findings provide an unexpected new link between inflammation and cardiac remodeling by de-repression of MEF2 through HDAC5 inactivation, which has potential implications for new strategies to treat inflammatory cardiomyopathies.
|
29907596 |
2018 |
|
Steatohepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Most important, hepatic overexpression of a phosphorylation-deficient mutant HDAC5 2SA promotes hepatic fatty acid oxidation gene expression and protects against hepatic steatosis in mice fed a high-fat diet.
|
29229738 |
2018 |