HDAC5, histone deacetylase 5, 10014

N. diseases: 114; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.060 Biomarker phenotype BEFREE HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer. 27177225 2016
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.010 Biomarker group BEFREE Histone deacetylase 5 (HDAC5) is an important protein in neural and cardiac diseases and a potential drug target. 27177225 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.050 AlteredExpression disease BEFREE HDAC5 was extensively expressed in human BC tissues, and high HDAC5 expression was associated with an inferior prognosis. 27177225 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 AlteredExpression disease BEFREE HDAC5 was extensively expressed in human BC tissues, and high HDAC5 expression was associated with an inferior prognosis. 27177225 2016
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.320 Biomarker disease BEFREE Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. 27482699 2016
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.320 Biomarker disease CTD_human Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. 27482699 2016
CUI: C0011644
Disease: Scleroderma
Scleroderma 		0.020 Biomarker disease BEFREE Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. 27482699 2016
CUI: C0026936
Disease: Mycoplasma Infections
Mycoplasma Infections 		0.010 Biomarker group BEFREE HDAC5 promotes Mycoplasma pneumoniae-induced inflammation in macrophages through NF-κB activation. 30738045 2019
CUI: C0333983
Disease: Hyperplastic Polyp
Hyperplastic Polyp 		0.010 Biomarker disease BEFREE Histone deacetylase 5 (HDAC5) is involved in the regulation of inflammation, however, whether it associates with immunity against MP infection is not determined. 30738045 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 AlteredExpression group BEFREE A comparative microarray analysis demonstrated a genome wide cooperative effect of HDAC5 and LSD1 on cancer-related gene expression. shRNA knockdown and sulforaphane inhibition of HDAC5/LSD1 exhibited similar effects on expression of HDAC5/LSD1 target genes. 29633255 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE A comparative microarray analysis demonstrated a genome wide cooperative effect of HDAC5 and LSD1 on cancer-related gene expression. shRNA knockdown and sulforaphane inhibition of HDAC5/LSD1 exhibited similar effects on expression of HDAC5/LSD1 target genes. 29633255 2018
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.200 Biomarker disease RGD A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. 18937310 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 AlteredExpression disease BEFREE A gene network approach showed that the EHMT1, EHMT2, MAPK1, MAPK3, MAP2K1, and HDAC5 genes, which are involved in transcription and chromatin regulation cellular signaling pathways, were also associated with cocaine dependence. 31116258 2020
CUI: C0410438
Disease: Primary osteoporosis
Primary osteoporosis 		0.010 Biomarker disease BEFREE A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. 19920351 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 PosttranslationalModification disease BEFREE Aberrant expression of several HDACs and copy number gains of HDAC3 and HDAC5 occur in HCC. 22322234 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE Accordingly, HDAC5 was weakly expressed in UC cell lines suggesting a possible tumor-suppressive function. 31052182 2019
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.010 Biomarker disease BEFREE Accordingly, HDAC3 inhibitors and HDAC5 nuclear boosters show protection from tachypacing-induced changes and therefore may represent interesting therapeutic options in clinical AF. 30321539 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.500 Biomarker disease PSYGENET Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.500 Biomarker disease RGD Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952 2014
CUI: C3496069
Disease: cocaine use
cocaine use 		0.010 GeneticVariation disease BEFREE Although a mutation in HDAC5 has been shown to cause hypersensitive responses to chronic cocaine use whether this response worsens during chronic early life stress has not been examined yet. 28025089 2017
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.010 GeneticVariation disease BEFREE Although a mutation in HDAC5 has been shown to cause hypersensitive responses to chronic cocaine use whether this response worsens during chronic early life stress has not been examined yet. 28025089 2017
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.200 Biomarker disease RGD Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. 21416250 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 Biomarker group BEFREE Class I histone deacetylases (HDACs) generally promote cell proliferation and tumorigenesis, whereas class IIA HDACs like HDAC4 and HDAC5 may promote or impede cancer development in a tissue-dependent manner. 31052182 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE Class I histone deacetylases (HDACs) generally promote cell proliferation and tumorigenesis, whereas class IIA HDACs like HDAC4 and HDAC5 may promote or impede cancer development in a tissue-dependent manner. 31052182 2019