CDKN2A, cyclin dependent kinase inhibitor 2A, 1029

N. diseases: 1314; N. variants: 146
Disease: Acute respiratory failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE We also demonstrated that sonic hedgehog (Shh) expression, in cooperation with loss of the Trp53 and Ink4a/Arf tumor suppressor loci, was sufficient to initiate the formation of early pancreatic lesions. 17611415 2007
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE This study examined genetic variants in the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene that encodes the p16(INK4a) and p14(ARF) tumor suppressors, and the isocitrate dehydrogenase 1 (IDH1) gene as potential markers of survival for 40 individuals with NDTMM GBMs (telomerase negative and ALT negative by standard assays), 50 individuals with telomerase, and 17 individuals with ALT positive tumors. 22046342 2011
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE The INK4a/ARF tumor suppressor gene locus is one of the major targets of Bmi-1. 24552182 2014
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 GeneticVariation disease BEFREE The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), which act as upstream regulators of the Rb-CDK4 and p53 pathways. 12375265 2002
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 AlteredExpression disease BEFREE Together, these results indicate that modest increases in the activity of the Ink4a/Arf tumor suppressor result in a beneficial cancer-resistant phenotype without affecting normal viability or aging. 15520276 2004
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 GeneticVariation disease BEFREE Deletion of the INK4a/ARF tumor suppressor locus and trisomy 3 also occurred almost exclusively in ABC DLBCLs and was associated with inferior outcome within this subtype. 18765795 2008
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE Thus, whereas germ-line mutations of PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 are not common events in familial glioma, outside of familial cancer syndromes, point mutations of p53 and hemizygous deletions and other rearrangements of the p16(INK4A)/p14(ARF) tumor suppressor region may account for a subset of familial glioma cases. 10797439 2000
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. 15029199 2004
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE The p16(INK4a) and p14(ARF) tumor suppressor genes (TSGs) are encoded within the CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the p53 and RB pathways. 15140233 2004
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 AlteredExpression disease BEFREE Expression of the ARF tumor suppressor is regulated by runt-related X1, suggesting that the inv(16) fusion protein (IFP) may repress ARF expression. 16199529 2005
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE These data suggest that expression of the Ink4a/Arf tumor suppressor locus is a robust biomarker, and possible effector, of mammalian aging. 15520862 2004
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 GeneticVariation disease BEFREE The INK4a-ARF (CDKN2A) locus, located on chromosome 9p21, encodes two functionally distinct tumor suppressor genes, p14(ARF) and p16(INK4a), that play active roles in the p53 and Rb tumor suppressive pathways, respectively. 12189502 2002
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 AlteredExpression disease BEFREE Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. 20723236 2010
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE The locus harbors the CDKN2A/ARF tumor suppressor gene, which encodes two cell cycle regulatory proteins cyclin dependent kinase 2A (p16(INK4a)) and alternate reading frame (p14(ARF)). 12538475 2003
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 GeneticVariation disease BEFREE We report here that experimental induction of E2a-Pbx1 enhances expression of BMI-1, a lymphoid oncogene whose product functions as a transcriptional repressor of the INK4A-ARF tumor suppressor locus. 14536079 2003
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE Although the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2-independent manner. 15989956 2005
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE Importantly, these data establish that the ARF-E2F-1 pathway is an extension of the p53-mdm2-ARF tumor suppressor network and is unlikely to constitute a p53-independent pathway for ARF function. 17630509 2007
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE The INK4a/ARF tumor suppressor: one gene--two products--two pathways. 9757829 1998
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 AlteredExpression disease BEFREE Here we show that the Wnt-effector Tcf1 is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus. 28346462 2017
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 GeneticVariation disease BEFREE Overall, somatic mutation of the INK4a/ARF tumor suppressor locus, resulting in functionally deficient p16 and possibly p14(ARF) proteins, seems to be a prevalent event in the development of SCCHN.Mol.Carcinog.30:26-36, 2001. 11255261 2001
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE Modeling INK4/ARF tumor suppression in the mouse. 17311533 2007
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 GeneticVariation disease BEFREE The cytotoxicity of 5-aza-2'-deoxycytidine (DAC) has been linked to demethylation of the INK4a/ARF tumor suppressor gene locus in various cell systems, but the causality of this association remains unproven. 19372550 2009
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.100 Biomarker disease BEFREE In Europe and North America, between 8-14% of melanoma patients have a family history of the disease, and a subset of these individuals possess germline mutations in the CDKN2A gene, which encodes the p16(INK4A) and p14(ARF) tumor suppressors. 17713569 2008