|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic alterations of the transcription factor IKZF1 ("IKAROS") are detected in around 15-30% of cases of <i>BCR-ABL</i>-negative B-cell precursor acute lymphoblastic leukemia.
|
28751559 |
2017 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ikaros (IKZF1) functions as a master regulator of hematopoiesis and a tumor suppressor in acute lymphoblastic leukemia (ALL).
|
26912004 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion (ΔIKZF1) is an important predictor of relapse in childhood B-cell precursor acute lymphoblastic leukemia.
|
27419633 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study.
|
26202931 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genomic profile of ETV6-ABL1 acute lymphoblastic leukemia resembled that of BCR-ABL1 and BCR-ABL1-like cases with 80% of patients having concurrent CDKN2A/B and IKZF1 deletions.
|
27229714 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data also suggest that high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of ALL and has significance in an integrated prognostic model for adult high-risk ALL.
|
27391346 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To confirm the hypothesis that illegitimate recombination activating gene protein (RAG)-mediated recombination events are involved in IKZF1 Δ3-6 deletion in BCR-ABL1 lymphoblastic leukaemia, we first demonstrated that the expression rates of RAG1 and RAG2, collectively called RAG, were higher in ALL and BC-CML (lymphoid).
|
27198500 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown evidence for association between risk of ALL and variation within IKZF1, ARID5B, CEBPE, CDKN2A, GATA3, and BM1-PIP4K2A genes.
|
26941364 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Philadelphia chromosome-like ALL is essentially heterogeneous; however, deletion mutations in the IKZF1 gene encoding the transcription factor IKAROS underlie many cases as a key factor inducing aggressive phenotypes and poor treatment responses.
|
26991355 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion was noted in nine B-ALL with t(9;22), one B-ALL with t(4;11), five B-ALL with a normal karyotype, and three B-ALL with nonrecurring karyotypic abnormalities.
|
27161658 |
2016 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1.
|
25727050 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We performed a comprehensive analysis of the impact of IKZF1(del) in a large cohort of children (n=1223) with BCR-ABL1-negative BCP-ALL treated in the EORTC-CLG trial 58951.
|
26050650 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Retinoids potentiated the activity of dasatinib in mouse and human BCR-ABL1 ALL, providing an additional therapeutic option in IKZF1-mutated ALL.
|
26321221 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis.
|
25012940 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletions were associated with B-cell precursor acute lymphoblastic leukemia (P=0.036), BCR-ABL1-positive acute lymphoblastic leukemia (P<0.001), and higher white blood cell counts (P=0.005).
|
25261097 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion.
|
26404892 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The clinical impact of IKZF1 deletions in paediatric B-cell precursor acute lymphoblastic leukaemia is independent of minimal residual disease stratification in Nordic Society for Paediatric Haematology and Oncology treatment protocols used between 1992 and 2013.
|
26018335 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia.
|
26069293 |
2015 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Children with the IKZF1 SNP had an increased risk of developing MLL-germline ALL in white children.
|
24564228 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also created IKZF1 knockdown B-ALL cell lines with over 50% reduction of Ikaros, mimicking haplosufficient Ikaros deletions, and again performed qPCR to investigate the downstream targets.
|
24976218 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since recently conducted genome-wide association (GWA) studies revealed that the common low-penetrance susceptibility allele at 7p12.2 (IKZF1 gene) confers an increased risk of pediatric ALL, we investigated whether the risk allele at rs4132601 also coexists with well-established prognostic factors, among 508 Polish pediatric patients with newly diagnosed ALL.
|
24597983 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.
|
24064621 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The findings from this meta-analysis suggest that IKZF1 deletion can be used to serve as an independent predictive factor in patients with ALL.
|
25335741 |
2014 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, IKZF1 has been implicated in roles involved in some hematologic traits or abnormalities, such as erythrocyte measures, myelofibrosis, and acute lymphoblastic leukemia (ALL), which may be common clinical manifestations or co-occurrence hematological diseases of patients with SLE.
|
22782532 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL) has been termed BCR-ABL1-like or Ph-like because of similarity of the gene expression profile to BCR-ABL1 positive ALL suggesting the presence of lesions activating tyrosine kinases, frequent alteration of IKZF1, and poor outcome.
|
23212523 |
2013 |