|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the need of and benefit from introducing IKZF1 deletions as an additional stratification marker for patients with Philadelphia-negative B-cell precursor acute lymphoblastic leukemia remain questionable.
|
23585525 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletions significantly affected event-free survival (EFS) of the ALL IC cohort (41 ± 14% vs. 86 ± 3%, P < 0.0001).
|
22997141 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that IKZF1 and TP53 represent relevant prognostic factors that should be considered in future risk assessment of children with relapsed ALL to indicate treatment intensification or intervention.
|
22699455 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.
|
23804397 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia.
|
23065506 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan.
|
23930217 |
2013 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified CRLF2 overexpression as an intermediate-risk marker and Ik6 variant of IKZF1 gene as a high-risk one when stratifying pediatric B-ALL cases according to cytogenetic/molecular risks.
|
22297722 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CRLF2-d, IGH@-t, and IKZF1 deletions are associated with poor outcome in adolescent and adult ALL.
|
22851563 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in genes regulating lymphoid development are a hallmark of ALL, and alterations of the lymphoid transcription factor gene IKZF1 (IKAROS) are associated with a high risk of treatment failure in B-ALL.
|
23233609 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations.
|
22441210 |
2012 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A subset of B-ALL patients with IKZF1 alterations have a transcriptional profile similar to BCR-ABL1-positive ALL, and these patients commonly have novel rearrangements and mutations resulting in aberrant cytokine receptor signaling and activation of kinase signaling cascades, including rearrangement of CRLF2 and activating mutations of Janus kinases (JAK1 and JAK2).
|
21149616 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed the status of BCR-ABL1 and IKZF1 genes in 2 pairs of monozygotic twins, one pair concordant, the other discordant for Philadelphia chromosome positive (Ph(+)) ALL.
|
21960589 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we determined the prognostic significance of IKZF1 deletions in patients with childhood ALL.
|
21740479 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Notably, genetic alterations targeting transcriptional regulators of lymphoid development are a hallmark of B-progenitor ALL, and alteration of specific genes in this pathway, such as IKZF1 (encoding IKAROS), are associated with high-risk ALL.
|
21169835 |
2011 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a high proportion of Philadelphia positive acute lymphoblastic leukaemia (ALL) patients, prognostically adverse deletions of the IKZF1 gene coding for a specific transcription factor were identified with GEP analysis, which revealed new insights in the clinical variability of this disorder.
|
20570445 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that, in ALL leukemogenesis, loss of CDKN2A and other target genes in the instability region is frequently associated with BCR/ABL1 and IKZF1 dysfunction.
|
20013897 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
|
20139093 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These classifiers were further validated on an independent high-risk ALL cohort (P = .006) and retainedindependent prognostic significance (P < .001) in the presence of other recently described poor prognostic factors (IKAROS/IKZF1 deletions, JAK mutations, and kinase expression signatures).
|
19880498 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Notably, genetic alteration of the lymphoid transcription factor gene IKZF1 is a hallmark of multiple subtypes of ALL with poor prognosis, including BCR-ABL1-positive lymphoid leukemia and a subset of 'BCR-ABL1-like' ALL cases that, in addition to IKZF1 alteration, harbor genetic mutations resulting in aberrant lymphoid cytokine receptor signaling, including activating mutations of Janus kinases and rearrangement of cytokine receptor-like factor 2 (CRLF2).
|
20739952 |
2010 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The gene-expression signature of the group of patients with a poor outcome revealed increased expression of hematopoietic stem-cell genes and reduced expression of B-cell-lineage genes, and it was similar to the signature of BCR-ABL1-positive ALL, another high-risk subtype of ALL with a high frequency of IKZF1 deletion.
|
19129520 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.
|
19770381 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings provide a rationale for the surprisingly high frequency of IKAROS deletions in Ph(+) ALL and identify IKAROS-mediated cell cycle exit as the endpoint of an emerging pathway of pre-B cell receptor-mediated tumor suppression.
|
19620627 |
2009 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deletion of IKZF1 was also identified as an acquired lesion at the time of transformation of CML to ALL (lymphoid blast crisis).
|
18408710 |
2008 |
|
Acute lymphocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.
|
16205638 |
2006 |