Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The first clinical trial of an avipox recombinant vaccine for patients with advanced carcinomas has recently been conducted using the ALVAC vector and the human carcinoembryonic antigen (CEA) transgene (designated ALVAC-CEA; J. L. Marshall et al, J. Clin.Oncol., 17: 332-337, 1999).
|
10656428 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MFE-23-his scFv antibody localizes in CEA-producing carcinomas.
|
10815889 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Upon co-culture with CEA(+) tumor cells, receptor-grafted T cells are specifically and efficiently activated to cytolysis and IFN-gamma secretion, demonstrating their feasibility for the adoptive immunotherapy of CEA(+) carcinomas.
|
10962448 |
2000 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA is an important tumor marker for colorectal and some other carcinomas.
|
10202129 |
1999 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Human carcinoembryonic antigen (CEA) is a well-characterized oncofetal glycoprotein whose overexpression by human carcinomas has been a target for cancer immunotherapy.
|
9973217 |
1999 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This system may be useful in gene therapy that targets CEA-producing gastric carcinomas.
|
8898638 |
1996 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To detect adenocarcinoma cells in the circulating peripheral blood, we "analyzed the presence of carcinoembryonic antigen (CEA) mRNA in the peripheral blood obtained from patients with pancreatic carcinoma (PC) or with gastric carcinoma (GC) and also, as controls, from pancreatitis or gastritis patients without carcinomas, a gastric lymphoma patient and four healthy volunteers.
|
8950323 |
1996 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that PCR amplification of CEA mRNA may lead to an earlier diagnosis of micrometastatic bone disease in patients with CEA-expressing carcinomas.
|
7512130 |
1994 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Definition of the expression of the human carcinoembryonic antigen and non-specific cross-reacting antigen in human breast and lung carcinomas.
|
8386136 |
1993 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Western blot analysis showed that the size of the recombinant CEA secreted by the transfected human cells is identical to that of reference CEA purified from human colon carcinomas metastases (about 200 kD).
|
7688074 |
1993 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When we compared the intensity of the hybridization signal for CEA or NCA mRNA among adenomas, carcinomas and adjacent noninvaded tissues, NCA mRNA rather than CEA mRNA was highly expressed in carcinomas compared to adjacent nonivaded tissues.
|
2067130 |
1991 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas CEA is a suitable marker for aneuploid carcinomas, other more sensitive tumour markers should be sought for diploid and also for tetraploid tumours.
|
1771385 |
1991 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is a 180-kDa glycoprotein expressed on most gastrointestinal carcinomas.
|
1860736 |
1991 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The intensity of signal appeared to be stronger in carcinomas than that in adenomas, and the CEA and NCA mRNAs were expressed together in most of the positive tissue specimens.
|
2125040 |
1990 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similarly to the 180 kd CEA molecules synthesized by carcinomas, the expression of the melanoma associated CEA like components (MA-CEA) is upregulated by IFN-alpha.
|
3235849 |
1989 |
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pre-operative CEA levels were measured in 100 patients with large bowel carcinomas with different DNA ploidy pattern and serial post-operative determinations performed in the 64 who had been operated for cure.
|
3816909 |
1986 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances.
|
824719 |
1976 |
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
However, assays of the tissue CEA content in six histologically verified adenomas showed values similar to those of overt colonic carcinomas.
|
1202622 |
1975 |