Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder.
|
19448850 |
2009 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia.
|
24064681 |
2013 |
Bipolar Disorder
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder.
|
18456508 |
2008 |
Bipolar Disorder
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.
|
23031404 |
2012 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
PDLIM5 may have a minor effect on susceptibility to BP in Caucasians.
|
18496208 |
2008 |
Bipolar Disorder
|
0.390 |
AlteredExpression
|
disease |
LHGDN |
In addition, we found the altered expression of LIM and HSPF1 both in the brains and lymphoblastoid cells in bipolar disorder.
|
14743183 |
2004 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia.
|
16044170 |
2005 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder.
|
18496210 |
2008 |
Bipolar Disorder
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia.
|
15362566 |
2004 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder.
|
19448850 |
2009 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia.
|
24064681 |
2013 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder.
|
18496210 |
2008 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia.
|
16044170 |
2005 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration.
|
23031404 |
2012 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it's expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression.
|
23593136 |
2013 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Nevertheless, after the western blot validation only two of the remaining proteins, namely LIM and SH3 domain protein1, and short-chain specific acyl-CoA dehydrogenase mitochondrial protein, resulted in being significantly upregulated in PBD samples suggesting additional mechanisms that could be associated with the psychotic features of bipolar disorder.
|
24554194 |
2014 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia.
|
18021463 |
2008 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
LHGDN |
Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia.
|
18021463 |
2008 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
PSYGENET |
These results suggest that PDLIM5 might play a role in genetic susceptibility to schizophrenia.
|
16213469 |
2006 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
These results suggest that PDLIM5 might play a role in genetic susceptibility to schizophrenia.
|
16213469 |
2006 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Further, we failed to find any genetic association between the PDLIM5 gene and schizophrenia with six single nucleotide polymorphics (SNPs) of the PDLIM5 gene in Japanese subjects (279 subjects each) and there was no significant relation between PDLIM5 gene and schizophrenia with the haplotype analysis (P=0.48), either.
|
17287082 |
2007 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Further, we failed to find any genetic association between the PDLIM5 gene and schizophrenia with six single nucleotide polymorphics (SNPs) of the PDLIM5 gene in Japanese subjects (279 subjects each) and there was no significant relation between PDLIM5 gene and schizophrenia with the haplotype analysis (P=0.48), either.
|
17287082 |
2007 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia.
|
18021463 |
2008 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001).
|
15362566 |
2004 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia.
|
24064681 |
2013 |