Cardiomyopathy, Dilated
|
0.220 |
Biomarker
|
group |
MGD |
|
|
|
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).
|
1923511 |
1991 |
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The fact that LIM domains can be found with or without associated homeodomain led to the suggestion that the LIM domains may function as regulators of transcription, and that alterations of transcription networks, after chromosomal translocations, lead to leukaemia.
|
8142620 |
1993 |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocations in T-cell acute leukemias can activate genes encoding putative transcription factors such as the LIM proteins RBTN1 and RBTN2 and the DNA-binding basic helix-loop-helix transcription factor TAL1 associated with T-cell acute lymphocytic leukemia.
|
8078932 |
1994 |
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.
|
7957052 |
1994 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM.
|
7789634 |
1995 |
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
hLH-2, a transcription factor that contains double cysteine rich regions (LIM motifs) and a homeobox (Hox) DNA-binding domain shows aberrant high expression in all cases of chronic myelogenous leukemia (CML).
|
7600533 |
1995 |
Trichohepatoenteric Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of a small hemizygous deletion in a patient with partial Williams syndrome suggests that loss of the LIM-Kinase1 gene may be responsible for the impaired visuospatial constructive cognition characteristic of the syndrome.
|
8939595 |
1996 |
Williams Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of a small hemizygous deletion in a patient with partial Williams syndrome suggests that loss of the LIM-Kinase1 gene may be responsible for the impaired visuospatial constructive cognition characteristic of the syndrome.
|
8939595 |
1996 |
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional activation of human LIM-HOX gene hLH-2 in chronic myelogenous leukemia is due to a cis-acting effect of Bcr-Abl.
|
9175786 |
1997 |
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 2
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional activation of human LIM-HOX gene hLH-2 in chronic myelogenous leukemia is due to a cis-acting effect of Bcr-Abl.
|
9175786 |
1997 |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.
|
9819382 |
1998 |
Nail-Patella Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Recently, LMX1B , a transcription factor of the LIM-homeodomain type with homologs that are important for limb development in vertebrates, was mapped to the same general location as NPS at 9q34.
|
9618165 |
1998 |
Nail-Patella Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Recent evidence shows that NPS is the result of mutations in the LIM-homeodomain gene LMX1B.
|
9837817 |
1998 |
Kidney Failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we provide evidence for the first described mutations in a LIM-homeodomain protein which account for an inherited form of abnormal skeletal patterning and renal failure.
|
9590287 |
1998 |
Trichohepatoenteric Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The syndrome is inherited in an autosomal dominant manner and has been shown to result from mutations in the LIM-homeodomain encoding LMX1B gene.
|
10571942 |
1999 |
Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Paxillin is a 68 kDa focal adhesion protein, with four tandem LIM domains at the C-terminus, involved in growth factor receptor, integrin and oncogenic signaling such as v-src, BCR/ABL, and E6 of the papilloma virus.
|
9926921 |
1999 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because of its high levels of expression in neoplastic tissues and the presence of both PDZ and LIM domains, we suggest that PCD1 may play an important role in cytoskeletal reorganization during carcinogenesis.
|
11016661 |
2000 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.
|
11734645 |
2001 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.
|
11734645 |
2001 |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
LMO4 belongs to a family of LIM-only transcriptional regulators, the first two members of which are oncoproteins in acute T cell leukemia.
|
11734645 |
2001 |
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
LIM 1215 colon cancer cells are therefore IGF-responsive but IGF-II is not a major autocrine factor for these cells in monolayer, suggesting heterogeneity between colon carcinoma cell lines with respect to the role of the IGF system.
|
11306178 |
2001 |
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
LIM 1215 colon cancer cells are therefore IGF-responsive but IGF-II is not a major autocrine factor for these cells in monolayer, suggesting heterogeneity between colon carcinoma cell lines with respect to the role of the IGF system.
|
11306178 |
2001 |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4.
|
12118377 |
2002 |
Childhood Pre-B Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4.
|
12118377 |
2002 |