PDLIM5, PDZ and LIM domain 5, 10611

N. diseases: 148; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4049796
Disease: Abnormality of cardiovascular system morphology
Abnormality of cardiovascular system morphology 		0.010 Biomarker disease BEFREE The LIM homeodomain transcriptor factor ISL1 is a marker for undifferentiated cardiac progenitor cells that give rise to both the right ventricle and the inflow and outflow tracts, which are affected by several cardiovascular malformations. 23229290 2013
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 Biomarker disease BEFREE Our data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis. 20573277 2010
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.010 Biomarker disease BEFREE In this study, we have determined the effect of ribozymes specific for LIM kinase-2 on metastatic and proliferative phenotypes of human fibrosarcoma cells. 15026997 2004
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.010 Biomarker disease BEFREE Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion. 31641031 2020
CUI: C3896961
Disease: Adult Pre-B Acute Lymphoblastic Leukemia
Adult Pre-B Acute Lymphoblastic Leukemia 		0.010 GeneticVariation disease BEFREE A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4. 12118377 2002
CUI: C0279550
Disease: Adult Rhabdomyosarcoma
Adult Rhabdomyosarcoma 		0.010 Biomarker disease BEFREE Wild-type and mutant IGFBP-6, as well as IGF-II, induced cell migration in RD rhabdomyosarcoma and LIM 1215 colon cancer cells. 17519236 2007
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.010 Biomarker disease BEFREE Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. 7957052 1994
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.010 GeneticVariation disease BEFREE Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. 27693979 2017
CUI: C0002871
Disease: Anemia
Anemia 		0.010 AlteredExpression disease BEFREE In the mouse, Lhx2, which encodes a member of the LIM (Lin-11, Isl-1, and Mec-3) class of homeodomain proteins, was shown to be expressed during early development in the posterior pituitary, eye, and liver, and its expression persists in adulthood in the central nervous system Lhx2(-/-) mice display absence of posterior pituitary and intermediate lobes, malformation of the anterior lobe, anophthalmia, and they die from anemia. 22535646 2012
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 GeneticVariation disease BEFREE The four and a half LIM domain protein 2 (FHL2) is a member of the four and a half LIM domain (FHL) gene family, and it is associated with cholesterol-enriched diet-promoted atherosclerosis. 31714683 2020
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.010 Biomarker disease BEFREE The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release. 28823868 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 GeneticVariation disease BEFREE The four and a half LIM domain protein 2 (FHL2) is a member of the four and a half LIM domain (FHL) gene family, and it is associated with cholesterol-enriched diet-promoted atherosclerosis. 31714683 2020
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.010 Biomarker group BEFREE We evaluated MEF2B expression, in comparison with additional GC markers, LIM domain-only transcription factor 2 (LMO2), and human GC-associated lymphoma (HGAL), in a variety of B-cell lymphomas, with particular emphasis on their utility in differentiating FL from MZL. 29309299 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder. 19448850 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder. 18456508 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration. 23031404 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE PDLIM5 may have a minor effect on susceptibility to BP in Caucasians. 18496208 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease LHGDN In addition, we found the altered expression of LIM and HSPF1 both in the brains and lymphoblastoid cells in bipolar disorder. 14743183 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. 16044170 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease LHGDN Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder. 18496210 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. 15362566 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder. 19448850 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder. 18496210 2008