PDLIM5, PDZ and LIM domain 5, 10611

N. diseases: 148; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Our genetic association study only offered evidence for susceptibility of PDLIM5 to bipolar disorder, but the positive SNP rs2433322 could not indicate a direct cause of this complicated brain disorder. 19448850 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder. 18456508 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration. 23031404 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE PDLIM5 may have a minor effect on susceptibility to BP in Caucasians. 18496208 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. 16044170 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. 15362566 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE Although the findings presented in this paper do not provide strong evidence that the PDLIM5 gene significantly affects the pathophysiology of BD, they suggest that rare variants within the promoter region of the gene may have a marginal effect on the disorder. 18496210 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE These results suggest that PDLIM5 might play a role in genetic susceptibility to schizophrenia. 16213469 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Further, we failed to find any genetic association between the PDLIM5 gene and schizophrenia with six single nucleotide polymorphics (SNPs) of the PDLIM5 gene in Japanese subjects (279 subjects each) and there was no significant relation between PDLIM5 gene and schizophrenia with the haplotype analysis (P=0.48), either. 17287082 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia. 18021463 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001). 15362566 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia. 24064681 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE The postsynaptic density-95/discs large/zone occludens-1 (PDZ) domain and LIM (Lin-11, Isl-1, and Mec-3) domain 5 (PDLIM5) gene has been analyzed as a candidate gene for both schizophrenia and bipolar disorder (BP) in Japanese samples. 18496208 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE The LIM and SH3 domain protein (LASP1) protein, a component of CNS synapses and dendritic spines, has been related to the N-methyl-D-aspartate receptor (NMDAR) dysfunction hypothesis and schizophrenia. 31827227 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. 16044170 2005
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE The PDZ and LIM domain 5 (PDLIM5) gene may play a role in alcohol dependence (AD), bipolar disorder, and major depressive disorder; however, no study has identified shared genetic variants within PDLIM5 gene among AD, type 2 diabetes (T2D), and hypertension. 27693979 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression. 16595163 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE These results support the hypothesis of a protective effect for the G allele of rs2433320 in the PDLIM5 gene in recurrent MDD. 18197271 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease BEFREE We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. 16044170 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease BEFREE We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. 16044170 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 GeneticVariation disease BEFREE The PDZ and LIM domain 5 (PDLIM5) gene may play a role in alcohol dependence (AD), bipolar disorder, and major depressive disorder; however, no study has identified shared genetic variants within PDLIM5 gene among AD, type 2 diabetes (T2D), and hypertension. 27693979 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 GeneticVariation disease BEFREE Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression. 16595163 2006
CUI: C0221765
Disease: Chronic schizophrenia
Chronic schizophrenia 		0.310 AlteredExpression disease BEFREE There was no difference in the PDLIM5 mRNA levels between chronic schizophrenic patients with antipsychotic medication and their controls. 17287082 2007
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.220 GeneticVariation group BEFREE It was demonstrated by both assays that the D626N mutation of Cypher/ZASP increased the affinity of the LIM domain for protein kinase C, suggesting a novel biochemical mechanism of the pathogenesis of dilated cardiomyopathy. 14660611 2004