|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we reprogrammed primary fibroblasts from two patients with familial Alzheimer's disease, both caused by a duplication of the amyloid-β precursor protein gene (APP; termed APP(Dp)), two with sporadic Alzheimer's disease (termed sAD1, sAD2) and two non-demented control individuals into iPSC lines.
|
22278060 |
2012 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that USP39 may act as an oncogenic factor in breast cancer and could be a potential molecular target for breast cancer gene therapy.
|
24126978 |
2013 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that USP39 may act as an oncogenic factor in breast cancer and could be a potential molecular target for breast cancer gene therapy.
|
24126978 |
2013 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We also found that p-Cdc2 was decreased in the USP39-overexpressing cells and was upregulated in the xenografted tumors derived from the HepG2/KD cells from nude mice.
|
26081192 |
2015 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The USP39 expression was significantly higher in the tumor tissues compared to the adjacent normal tissues, and was strongly associated with the pathological grade of HCC.
|
26081192 |
2015 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the functions of USP39 in human hepatocellular carcinoma (HCC) cell line SMMC-7721.
|
25889525 |
2015 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Previous studies showed that USP39 is related with tumorigenesis of human breast cancer cells.
|
25889525 |
2015 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231.
|
25812575 |
2015 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231.
|
25812575 |
2015 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Knockdown of USP39 in PCa cells inhibited cancer colony formation and tumor cell growth, and induced G2/M arrest and cell apoptosis.
|
26959883 |
2016 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Previous studies have shown that ubiquitin-specific protease 39 (USP39) is upregulated in several cancers and associated with tumor malignant characters.
|
27629785 |
2016 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.
|
27629785 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In this study, we aimed to investigate the functional relationship between OSCC and a potential tumor related gene ubiquitin-specific proteases 39 (USP39).
|
26835714 |
2016 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Knockdown of USP39 in PCa cells inhibited cancer colony formation and tumor cell growth, and induced G2/M arrest and cell apoptosis.
|
26959883 |
2016 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.
|
26959883 |
2016 |
|
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggested that USP39 is involved in the proliferation of GCs and may be utilized as a molecular target for GC therapy.
|
27175747 |
2016 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our study indicates that USP39 may be functionally involved in lung cancer growth and act as a potential molecular target for human lung cancer diagnosis and treatment.
|
27629785 |
2016 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our study indicates that USP39 may be functionally involved in lung cancer growth and act as a potential molecular target for human lung cancer diagnosis and treatment.
|
27629785 |
2016 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggested that USP39 is involved in the proliferation of GCs and may be utilized as a molecular target for GC therapy.
|
27175747 |
2016 |
|
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our study indicates that USP39 may be functionally involved in lung cancer growth and act as a potential molecular target for human lung cancer diagnosis and treatment.
|
27629785 |
2016 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma.
|
26835714 |
2016 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, the inhibition of USP39 expression decreased the phosphorylation of extracellular signal-regulated kinase (ERK)1/2, indicating that ERK signaling pathways might be involved in the regulation of melanoma cell proliferation by USP39.
|
27456357 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our cell-based study showed that the expression level of USP39 was the highest in AR-negative PCa cell lines.
|
26959883 |
2016 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our cell-based study showed that the expression level of USP39 was the highest in AR-negative PCa cell lines.
|
26959883 |
2016 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
USP39 Deubiquitinase Is Essential for <i>KRAS</i> Oncogene-driven Cancer.
|
28154181 |
2017 |