|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
USP39 c.*208G > C was strongly associated with triple-negative breast tumors (p = 0.0001).
|
31754952 |
2020 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation.
|
31332287 |
2019 |
|
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that the expression of <i>USP39</i> was up-regulated in human leukemia cells and the high expression of <i>USP39</i> was correlated with poor survival of the patients with leukemia.
|
30898977 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
USP39 knockdown led to the inhibition of cell migration and invasion.
|
31180526 |
2019 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that the expression of <i>USP39</i> was up-regulated in human leukemia cells and the high expression of <i>USP39</i> was correlated with poor survival of the patients with leukemia.
|
30898977 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The siRNA‑directed RNA interference targeting USP39 could effectively downregulate the expression level of USP39 in two RCC cell lines.
|
29328477 |
2018 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, we found SAD1/UNC84 domain protein-2 (SUN2) gene hypermethylation at CpG sites during liver fibrogenesis in mice with CCl<sub>4</sub>-induced hepatic fibrosis, which was accompanied by low expression of SUN2.
|
30282980 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of ubiquitin‑specific peptidase 39 inhibits the malignant progression of human renal cell carcinoma.
|
29328477 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, all these findings demonstrated that USP39 protein plays an important role in the growth and metastasis of colorectal cancer mainly through Wnt/β-catenin pathway.
|
28259917 |
2017 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, we demonstrated that overexpression of USP39 is closely correlated with tumor progression and poor survival in PC patients.
|
28286270 |
2017 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our data provide a novel PC regulatory axis that is miR-133a/USP39, the dysfunction of which drives diverse aspects of the progression of PC.
|
28286270 |
2017 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our data provide a novel PC regulatory axis that is miR-133a/USP39, the dysfunction of which drives diverse aspects of the progression of PC.
|
28286270 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, all these findings demonstrated that USP39 protein plays an important role in the growth and metastasis of colorectal cancer mainly through Wnt/β-catenin pathway.
|
28259917 |
2017 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma.
|
26835714 |
2016 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, the inhibition of USP39 expression decreased the phosphorylation of extracellular signal-regulated kinase (ERK)1/2, indicating that ERK signaling pathways might be involved in the regulation of melanoma cell proliferation by USP39.
|
27456357 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our cell-based study showed that the expression level of USP39 was the highest in AR-negative PCa cell lines.
|
26959883 |
2016 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our cell-based study showed that the expression level of USP39 was the highest in AR-negative PCa cell lines.
|
26959883 |
2016 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231.
|
25812575 |
2015 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231.
|
25812575 |
2015 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we reprogrammed primary fibroblasts from two patients with familial Alzheimer's disease, both caused by a duplication of the amyloid-β precursor protein gene (APP; termed APP(Dp)), two with sporadic Alzheimer's disease (termed sAD1, sAD2) and two non-demented control individuals into iPSC lines.
|
22278060 |
2012 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Research has demonstrated that SAD1/UNC84 domain protein-2 (SUN2) serves a suppressive role in breast cancer, atypical teratoid/rhabdoid tumors and lung cancer progression.
|
30675193 |
2019 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Research has demonstrated that SAD1/UNC84 domain protein-2 (SUN2) serves a suppressive role in breast cancer, atypical teratoid/rhabdoid tumors and lung cancer progression.
|
30675193 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Research has demonstrated that SAD1/UNC84 domain protein-2 (SUN2) serves a suppressive role in breast cancer, atypical teratoid/rhabdoid tumors and lung cancer progression.
|
30675193 |
2019 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Research has demonstrated that SAD1/UNC84 domain protein-2 (SUN2) serves a suppressive role in breast cancer, atypical teratoid/rhabdoid tumors and lung cancer progression.
|
30675193 |
2019 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, USP39 may prove to be a promising therapeutic target for patients with ovarian cancer.
|
31180526 |
2019 |