|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.
|
27629785 |
2016 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
USP39 Deubiquitinase Is Essential for <i>KRAS</i> Oncogene-driven Cancer.
|
28154181 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
USP39 Deubiquitinase Is Essential for <i>KRAS</i> Oncogene-driven Cancer.
|
28154181 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
USP39 knockdown inhibited xenograft tumor growth in nude mice and led to the downregulation of the transcription factor Forkhead Box M1 (FoxM1).
|
28413501 |
2017 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Ubiquitin specific peptidase 39 (USP39) serves important roles in mRNA processing and is involved in tumorigenesis of multiple solid malignancies.
|
29328477 |
2018 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Ubiquitin specific peptidase 39 (USP39) serves important roles in mRNA processing and is involved in tumorigenesis of multiple solid malignancies.
|
29328477 |
2018 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Ubiquitin-specific peptidase 39 (USP39) has been reported to participate in the mitotic spindle checkpoint and the process of cytokinesis. and has been identified as a therapeutic target for various types of cancer.
|
29556295 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Ubiquitin-specific peptidase 39 (USP39) has been reported to participate in the mitotic spindle checkpoint and the process of cytokinesis. and has been identified as a therapeutic target for various types of cancer.
|
29556295 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
USP39 knockdown led to the inhibition of cell migration and invasion.
|
31180526 |
2019 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
USP39 c.*208G > C was strongly associated with triple-negative breast tumors (p = 0.0001).
|
31754952 |
2020 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Expression of Concern to: Lentivirus mediated silencing of Ubiquitin Specific Peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro.
|
29933754 |
2018 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Furthermore, USP39 is proved to be associated with the proliferation of malignant tumors.
|
31637536 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, the inhibition of USP39 expression decreased the phosphorylation of extracellular signal-regulated kinase (ERK)1/2, indicating that ERK signaling pathways might be involved in the regulation of melanoma cell proliferation by USP39.
|
27456357 |
2016 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we reprogrammed primary fibroblasts from two patients with familial Alzheimer's disease, both caused by a duplication of the amyloid-β precursor protein gene (APP; termed APP(Dp)), two with sporadic Alzheimer's disease (termed sAD1, sAD2) and two non-demented control individuals into iPSC lines.
|
22278060 |
2012 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, we demonstrated that overexpression of USP39 is closely correlated with tumor progression and poor survival in PC patients.
|
28286270 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, USP39 may be a novel biological marker for targeted therapy against CRC, and requires further investigation.
|
29556295 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231.
|
25812575 |
2015 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231.
|
25812575 |
2015 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the functions of USP39 in human hepatocellular carcinoma (HCC) cell line SMMC-7721.
|
25889525 |
2015 |
|
Malignant neoplasm of ovary
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we observed that USP39 was frequently overexpressed in human ovarian cancer and was highly correlated with TNM stage.
|
31637536 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we observed that USP39 was frequently overexpressed in human ovarian cancer and was highly correlated with TNM stage.
|
31637536 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In this study, we aimed to investigate the functional relationship between OSCC and a potential tumor related gene ubiquitin-specific proteases 39 (USP39).
|
26835714 |
2016 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, we found SAD1/UNC84 domain protein-2 (SUN2) gene hypermethylation at CpG sites during liver fibrogenesis in mice with CCl<sub>4</sub>-induced hepatic fibrosis, which was accompanied by low expression of SUN2.
|
30282980 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In vivo animal models revealed that the subcutaneous transplantation and intraperitoneal injection of USP39‑overexpressing ES2 cells increased tumor burden with or without treatment with carboplatin.
|
31180526 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma.
|
26835714 |
2016 |