|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
The significant differences in the expression of Nischarin between: i) Cancer tissue and noncancerous tissue and ii) patients with and without lymph node metastasis, suggested that Nischarin may have a significant role in tumor occurrence and metastasis of breast cancer.
|
25695373 |
2015 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Nischarin (NISCH) is a cytoplasmic protein known to serve an inhibitory role in breast cancer cell apoptosis, migration and invasion.
|
30651848 |
2019 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Furthermore, we discuss data illustrating a novel role of Nischarin as a tumor suppressor in breast cancer.
|
26392073 |
2015 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.
|
30635277 |
2019 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
CTD_human |
In summary, this project provides further clarity concerning the function of Malat1, specifically in breast cancer, while also indicating that the Nischarin expression context is an important factor in the determining how Malat1 activity is governed in breast cancer.
|
29912916 |
2018 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer.
|
29415725 |
2018 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our study aimed to analyze the association between Nischarin expression and clinical features of breast cancer patients, and further investigate the role of Nischarin in breast cancer cells apoptosis, migration and invasion.
|
28131840 |
2017 |
|
Breast Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
We subsequently described a role for Nischarin in breast cancer, in which it is frequently underexpressed.
|
31525254 |
2020 |
|
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
Our studies, for the first time, demonstrate functional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression.
|
23572524 |
2013 |
|
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer.
|
29912916 |
2018 |
|
Hypotension
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
|
11486246 |
2001 |
|
Hypotension
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Adenosinergic modulation of the imidazoline I₁-receptor-dependent hypotensive effect of ethanol in acute renal failure.
|
22613216 |
2012 |
|
Bradycardia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
|
11486246 |
2001 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer.
|
29912916 |
2018 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer.
|
29912916 |
2018 |
|
Hypertensive disease
|
0.210 |
Biomarker
|
group |
RGD |
Imidazoline receptors in the heart: characterization, distribution, and regulation.
|
12021582 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Nischarin interacts with a number of signaling proteins such as Integrin α5, PAK1, LIMK1, LKB1, and Rac1 to prevent cancer cell migration.
|
29415725 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we discuss data illustrating a novel role of Nischarin as a tumor suppressor in breast cancer.
|
26392073 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the absence of Nischarin and LKB1 increased tumor growth in vivo.
|
23572524 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study identified a novel function of the tumor suppressor Nischarin in exosome biology and cancer progression.<i>See related article by Maziveyi et al., p. 2152</i>.
|
31043427 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The significant differences in the expression of Nischarin between: i) Cancer tissue and noncancerous tissue and ii) patients with and without lymph node metastasis, suggested that Nischarin may have a significant role in tumor occurrence and metastasis of breast cancer.
|
25695373 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Exosomes secreted by Nischarin-expressing tumors inhibited tumor growth.
|
30635277 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we show for the first time, metformin activates AMPK signaling and inhibits tumor growth of Nischarin lacking PyMT tumors suggesting a potential use for metformin as a cancer therapeutic, particularly in the case of Nischarin-deficient breast cancers.
|
31525254 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that NISCH was significantly downregulated, which correlated considerably with advanced tumor stage, poor differentiation, lymph node metastasis, and the serous/mucinous subtypes in a panel of ovarian cancer tissues.
|
25724667 |
2015 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Our data show that Nischarin prevents cell migration and invasion by altering the expression of key focal adhesion proteins.
|
29415725 |
2018 |