CHRM4, cholinergic receptor muscarinic 4, 1132

N. diseases: 33; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234379
Disease: Resting Tremor
Resting Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0234381
Disease: Darkness Tremor
Darkness Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0235078
Disease: Tremor, Perioral
Tremor, Perioral 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0235081
Disease: Tremor, Limb
Tremor, Limb 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0235082
Disease: Tremor, Muscle
Tremor, Muscle 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0235083
Disease: Nerve Tremors
Nerve Tremors 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0235843
Disease: Tremor, Neonatal
Tremor, Neonatal 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0751564
Disease: Pill Rolling Tremor
Pill Rolling Tremor 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0751565
Disease: Tremor, Semirhythmic
Tremor, Semirhythmic 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C1527384
Disease: Involuntary Quiver
Involuntary Quiver 		0.300 Biomarker phenotype CTD_human Characterization of the muscarinic receptor subtype mediating pilocarpine-induced tremulous jaw movements in rats. 9920179 1999
CUI: C0018801
Disease: Heart failure
Heart failure 		0.200 Biomarker disease RGD Regulation of neuronal type genes in congestive heart failure rats. 16497176 2006
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.200 Biomarker disease RGD In CHF hearts, the expression of the muscarinic m4 (Chrm4) and nicotinic alpha4 (Chrna4) acetylcholin receptors, the ATP receptor P2rx4, nerve growth factor receptor (Ngfr), discoidin domain receptor 1 (Ddr1), neuronal pentraxin receptor (Nptxr), peripheral myelin protein Pmp-22, leukocyte type 12-lipoxygenase (Alox15), cytochrome P450 4F5 (Cyp4F5) and cardiac Kcne1 were all increased (range 1.6-6.0-fold, P < 0.01 for all genes). 16497176 2006
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.010 Biomarker group BEFREE Here, we found that the muscarinic acetylcholine receptor, cholinergic receptor, muscarinic 4 (CHRM4), pathway regulates BFU-E self-renewal and that pharmacological inhibition of CHRM4 corrects anemias of myelodysplastic syndrome (MDS), aging, and hemolysis. 31554738 2019
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.010 GeneticVariation disease BEFREE Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (Pcorrected = 0.047). 27269905 2016
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 GeneticVariation group BEFREE These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders. 23490763 2013
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 GeneticVariation phenotype BEFREE These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders. 23490763 2013