Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The analysis of the COMT haplotypes revealed an association of the A-G haplotype with EPS risk in the overall group and the bipolar disorder subgroup, and an association of the A-A haplotype with EPS protection in the bipolar subgroup.
|
18922583 |
2008 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study supports the hypothesis the interaction of the dopaminergic genes between BP-II(+AD) and BP-II(-AD) is significant different,, and provides additional evidence that the DRD2TaqIA A1/A1, ALDH2*1/*1 and COMT genes interact in BP-II(-AD) but not in BP-II(+AD).
|
25430946 |
2015 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and in healthy controls.
|
22222175 |
2012 |
Bipolar Disorder
|
0.700 |
PosttranslationalModification
|
disease |
LHGDN |
These findings suggest that MB-COMT over-expression due to promoter hypomethylation and/or hyperactive allele of COMT may increase dopamine degradation in the frontal lobe providing a molecular basis for the shared symptoms of schizophrenia and bipolar disorder.
|
16984965 |
2006 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder.
|
18571901 |
2008 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.
|
20122740 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder.
|
18571901 |
2008 |
Bipolar Disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The methylation level of COMT and PPIEL gene is closely related to bipolar disorder.
|
29565503 |
2018 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]).
|
28544426 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives.
|
20667170 |
2011 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants.
|
19025226 |
2008 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
A gene coexpression network was developed based on a mutual information approach including four candidate genes (NRG1, DISC1, BDNF and COMT) along with other coexpressing genes in unipolar disorder, bipolar disorder and schizophrenia.
|
22777684 |
2012 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory.
|
16542182 |
2006 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function.
|
25744938 |
2015 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MAOA and COMT genes may not influence suicidal behavior in patients with bipolar disorder.
|
15936529 |
2005 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we first investigate the possible association between the Val/Met polymorphism in COMT and bipolar disorder in the Han population, which has never been done before.
|
19578924 |
2009 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report.
|
16542735 |
2006 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings seem to indicate a role of COMT polymorphisms in regulating cognitive functioning in patients with BD.
|
30146088 |
2019 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.
|
9264133 |
1997 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders.
|
11772685 |
2002 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The lack of association suggests that the COMT gene is not a major risk factor for bipolar disorder.
|
8988970 |
1997 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD.
|
22713126 |
2012 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The catechol-O-methyltransferase (COMT) gene has been a candidate gene for BD.
|
27930497 |
2017 |