COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The analysis of the COMT haplotypes revealed an association of the A-G haplotype with EPS risk in the overall group and the bipolar disorder subgroup, and an association of the A-A haplotype with EPS protection in the bipolar subgroup. 18922583 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE This study supports the hypothesis the interaction of the dopaminergic genes between BP-II(+AD) and BP-II(-AD) is significant different,, and provides additional evidence that the DRD2TaqIA A1/A1, ALDH2*1/*1 and COMT genes interact in BP-II(-AD) but not in BP-II(+AD). 25430946 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and in healthy controls. 22222175 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. 20122740 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder. 18571901 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 AlteredExpression disease BEFREE The methylation level of COMT and PPIEL gene is closely related to bipolar disorder. 29565503 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]). 28544426 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives. 20667170 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants. 19025226 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory. 16542182 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE These findings suggest that MAOA and COMT genes may not influence suicidal behavior in patients with bipolar disorder. 15936529 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE In this study, we first investigate the possible association between the Val/Met polymorphism in COMT and bipolar disorder in the Han population, which has never been done before. 19578924 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported. 19193231 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report. 16542735 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE These findings seem to indicate a role of COMT polymorphisms in regulating cognitive functioning in patients with BD. 30146088 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder. 9264133 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders. 11772685 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE The lack of association suggests that the COMT gene is not a major risk factor for bipolar disorder. 8988970 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD. 22713126 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE The catechol-O-methyltransferase (COMT) gene has been a candidate gene for BD. 27930497 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 AlteredExpression disease BEFREE It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism. 10395222 1999
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. 23026378 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Other reported associations of COMT with obsessive compulsive and rapid cycling bipolar disorder indicate that the COMT gene may have complex and pleiotropic effects on susceptibility and symptomatology of neuropsychiatric disorders. 9323320 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 AlteredExpression disease BEFREE Nevertheless, the specific relevance of COMT enzymatic activity in the pathophysiology of BD and schizophrenia dimensions remains elusive. 27458023 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE We found three candidate genes associated with both BD and TUD (COMT, SLC6A3, and SLC6A4) and commonality analysis suggests that these genes interact in predisposing psychiatric and substance use disorders. 20102619 2010