COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease HPO
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE The lack of association suggests that the COMT gene is not a major risk factor for bipolar disorder. 8988970 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder. 9264133 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Other reported associations of COMT with obsessive compulsive and rapid cycling bipolar disorder indicate that the COMT gene may have complex and pleiotropic effects on susceptibility and symptomatology of neuropsychiatric disorders. 9323320 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group. 9330018 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE We hypothesize that either the low activity allele of catechol-O-methyltransferase is a risk factor for bipolar affective disorder in Chinese populations or is in linkage disequilibrium with a nearby susceptibility gene or polymorphism. 9352569 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder. 9702744 1998
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE There is evidence implicating COMT as a candidate gene for a number of neuropsychiatric conditions including bipolar disorder. 9861640 1998
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 AlteredExpression disease BEFREE It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism. 10395222 1999
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders. 11772685 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease CTD_human Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes. 11772685 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE A significant association between bipolar disorder and COMT polymorphisms was found. 15211633 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease LHGDN A significant association between bipolar disorder and COMT polymorphisms was found. 15211633 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE These findings suggest that MAOA and COMT genes may not influence suicidal behavior in patients with bipolar disorder. 15936529 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory. 16542182 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report. 16542735 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Moreover, COMT was risk factor for onset of both major depression and bipolar disorder, in conjunction with adversities. 16756688 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 PosttranslationalModification disease LHGDN These findings suggest that MB-COMT over-expression due to promoter hypomethylation and/or hyperactive allele of COMT may increase dopamine degradation in the frontal lobe providing a molecular basis for the shared symptoms of schizophrenia and bipolar disorder. 16984965 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered promoter methylation and the nature of the contribution of COMT Val158Met polymorphism as risk factors for schizophrenia and bipolar disorder by analyzing 115 post-mortem brain samples from the frontal lobe. 16984965 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE To determine whether the COMT gene is associated with personality traits related to genetic risk for either schizophrenia or bipolar disorder, we examined dimensions of personality psychopathology in biological relatives of individuals with the disorders. 18201871 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease LHGDN Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder. 18571901 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder. 18571901 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genetic variation at the catechol-O-methyltransferase (COMT) gene has been significantly associated with risk for various neuropsychiatric conditions such as schizophrenia, panic disorder, bipolar disorders, anorexia nervosa and others. 18574484 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The analysis of the COMT haplotypes revealed an association of the A-G haplotype with EPS risk in the overall group and the bipolar disorder subgroup, and an association of the A-A haplotype with EPS protection in the bipolar subgroup. 18922583 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants. 19025226 2008