ADORA1, adenosine A1 receptor, 134

N. diseases: 121; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 GeneticVariation disease UNIPROT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 Biomarker disease BEFREE Taken together, these results indicate that metformin suppresses human colorectal cancer growth by inducing apoptosis via ADORA1, which provide evidence the anti-neoplastic effects of metformin in the treatment of human colorectal cancer. 27814614 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease BEFREE Therefore, we investigated the contribution of genetic variations of ADORA1 to the pathophysiological mechanisms of Japanese schizophrenia patients. 19820430 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET Therefore, we investigated the contribution of genetic variations of ADORA1 to the pathophysiological mechanisms of Japanese schizophrenia patients. 19820430 2009
CUI: C0007370
Disease: Catalepsy
Catalepsy 		0.300 Therapeutic disease CTD_human Effect of adenosine receptor agonists and antagonists on morphine-induced catalepsy in mice. 9407998 1997
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Therapeutic disease CTD_human Role of adenosine in delayed preconditioning of myocardium. 12160945 2002
CUI: C0033054
Disease: Prenatal Exposure Delayed Effects
Prenatal Exposure Delayed Effects 		0.300 Biomarker disease CTD_human Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring. 19092996 2008
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.300 Biomarker disease CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. 16226742 2005
CUI: C0472381
Disease: Posterior Circulation Transient Ischemic Attack
Posterior Circulation Transient Ischemic Attack 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0740376
Disease: Middle Cerebral Artery Thrombosis
Middle Cerebral Artery Thrombosis 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0751019
Disease: Carotid Circulation Transient Ischemic Attack
Carotid Circulation Transient Ischemic Attack 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0751020
Disease: Transient Ischemic Attack, Vertebrobasilar Circulation
Transient Ischemic Attack, Vertebrobasilar Circulation 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0751021
Disease: Crescendo Transient Ischemic Attacks
Crescendo Transient Ischemic Attacks 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0751022
Disease: Brain Stem Ischemia, Transient
Brain Stem Ischemia, Transient 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0917805
Disease: Transient Cerebral Ischemia
Transient Cerebral Ischemia 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C1527335
Disease: Transient Ischemic Attack, Anterior Circulation
Transient Ischemic Attack, Anterior Circulation 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.210 Biomarker disease BEFREE However, little is known about whether ADORA1 takes part in the course of neuronal cell injury after intermittent hypoxia exposure which was the main pathological characteristic of OSAHS. 29380238 2018
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.210 Biomarker disease RGD Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors. 18787037 2008
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.200 Biomarker disease RGD Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. 17067559 2006
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic disease RGD Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia. 9597368 1998
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. 11593763 2000