|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats?
|
15641640 |
2004 |
|
Agnosia for Pain
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results indicated that the adenosine A1 receptor is involved in EA actions during neuropathic pain through suppressing astrocyte activation as well as TNF-α upregulation of EA, giving enlightenment to the mechanisms of acupuncture analgesia and development of therapeutic targets for neuropathic pain.
|
30570016 |
2018 |
|
Agnosia for Pain
|
0.020 |
Biomarker
|
disease |
BEFREE |
In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose.
|
28611421 |
2017 |
|
Airway Obstruction
|
0.010 |
AlteredExpression
|
group |
BEFREE |
EPI-2010 has been shown to inhibit adenosine A(1) receptor expression and significantly improve allergen-induced airway obstruction and bronchial hyper-responsiveness in animal models of human asthma.
|
11728229 |
2001 |
|
Akathisia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Haplotype analysis showed an association between ADORA1 CTCAACG haplotype and overall psychopathological symptoms (p = 0.019), positive psychopathological symptoms (p = 0.021), and akathisia (p = 0.028).
|
27195966 |
2016 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor.
|
30365112 |
2019 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Studies with caffeine and <sup>6</sup>N-cyclohexyladenosine, a non-selective antagonist and a selective agonist of adenosine A1 receptor (A1AR) respectively, indicated the involvement of adenosine receptor (AR) signaling.
|
29097738 |
2017 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A direct injection of adenosine A1 receptor agonist or histamine H1 receptor agonist increased β-endorphin in the cerebral-spinal fluid in the acute adjuvant arthritis male rats and thus replicated the analgesic effect of acupuncture.
|
29695862 |
2018 |
|
Asthma
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
EPI-2010 has been shown to inhibit adenosine A(1) receptor expression and significantly improve allergen-induced airway obstruction and bronchial hyper-responsiveness in animal models of human asthma.
|
11728229 |
2001 |
|
Asthma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Pharmacological approach of translation in asthma includes therapeutic ribozymes and antisense oligonucleotides targeting receptors (adenosine A1 receptor, alpha chain of IL-5 receptor, common beta chain of IL-3/IL-5/GM-CSF receptor), cytokines (IL-4, IL-5, SCF), signal transduction molecules (Syk, Lyn), transcription factors (STAT-6, GATA-3).
|
14754517 |
2004 |
|
Asthma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Asthma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Bipolar Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder.
|
9514582 |
1998 |
|
Bradycardia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
|
18313046 |
2008 |
|
Brain Stem Ischemia, Transient
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia.
|
23437309 |
2013 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that Adora1 may represent an important target for therapeutic intervention in hormone-dependent breast cancer.
|
19935720 |
2010 |
|
Caffeine related disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose.
|
28611421 |
2017 |
|
Caffeine related disorders
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Administration of escitalopram or fluoxetine followed by caffeine withdrawal caused an increase in this gene expression, whereas administration of escitalopram, but not fluoxetine, on day 15th together with caffeine caused a decrease in Adora1 mRNA level in the Cx.
|
29107002 |
2017 |
|
Caffeine related disorders
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Withdrawal of caffeine after its chronic administration modifies the antidepressant-like activity of atypical antidepressants in mice. Changes in cortical expression of Comt, Slc6a15 and Adora1 genes.
|
29882086 |
2018 |
|
Caffeine related disorders
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Caffeine increased the protein levels of A<sub>1</sub>R without altering ADORA1 mRNA and was devoid of effects on A<sub>2A</sub>R density or ADORA2A mRNA levels.
|
31563462 |
2019 |
|
Caffeine withdrawal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Caffeine withdrawal caused a decrease in Adora1 mRNA level in the cerebral cortex (Cx).
|
29107002 |
2017 |