ADORA1, adenosine A1 receptor, 134

N. diseases: 121; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 GeneticVariation disease UNIPROT
CUI: C0021368
Disease: Inflammation
Inflammation 		0.200 Biomarker phenotype RGD The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats. 2167912 1990
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker group RGD These data indicate that adenosine A1 receptor antagonism reduces salt-induced hypertension and the consequent renal injuries. 8998253 1995
CUI: C0007370
Disease: Catalepsy
Catalepsy 		0.300 Therapeutic disease CTD_human Effect of adenosine receptor agonists and antagonists on morphine-induced catalepsy in mice. 9407998 1997
CUI: C0233612
Disease: Waxy flexibility
Waxy flexibility 		0.300 Therapeutic phenotype CTD_human Effect of adenosine receptor agonists and antagonists on morphine-induced catalepsy in mice. 9407998 1997
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 Biomarker disease BEFREE New pharmacological approaches to NIDDM and obesity have focused on insulin-sensitizing agents (e.g. troglitazone), beta3-AR agonists, anti-lipolytic drugs (e.g. the adenosine A1 receptor agonist GR79236) and selective inhibitors of PKC isoforms (e.g. the inhibitor of PKC-beta LY333531). 9493493 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.010 Biomarker disease BEFREE New pharmacological approaches to NIDDM and obesity have focused on insulin-sensitizing agents (e.g. troglitazone), beta3-AR agonists, anti-lipolytic drugs (e.g. the adenosine A1 receptor agonist GR79236) and selective inhibitors of PKC isoforms (e.g. the inhibitor of PKC-beta LY333531). 9493493 1998
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C2700438
Disease: MAJOR AFFECTIVE DISORDER 7
MAJOR AFFECTIVE DISORDER 7 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C2700439
Disease: MAJOR AFFECTIVE DISORDER 8
MAJOR AFFECTIVE DISORDER 8 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C2700440
Disease: MAJOR AFFECTIVE DISORDER 9
MAJOR AFFECTIVE DISORDER 9 		0.010 GeneticVariation disease BEFREE Our data suggest that genetically determined variation of the A1AR and its two promoters do not play a major role in the development of bipolar affective disorder. 9514582 1998
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic disease RGD Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia. 9597368 1998
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Therapeutic group RGD Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia. 9597368 1998
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 AlteredExpression disease BEFREE Several lines of experimental evidence suggest that an excess of adenosine A1 receptor activity may contribute to adiposity in NIDDM. 10459555 1999
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. 11593763 2000
CUI: C0004096
Disease: Asthma
Asthma 		0.130 AlteredExpression disease BEFREE EPI-2010 has been shown to inhibit adenosine A(1) receptor expression and significantly improve allergen-induced airway obstruction and bronchial hyper-responsiveness in animal models of human asthma. 11728229 2001
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction 		0.010 AlteredExpression group BEFREE EPI-2010 has been shown to inhibit adenosine A(1) receptor expression and significantly improve allergen-induced airway obstruction and bronchial hyper-responsiveness in animal models of human asthma. 11728229 2001
CUI: C1531647
Disease: Cerebral ventriculomegaly
Cerebral ventriculomegaly 		0.200 Biomarker phenotype RGD A1 adenosine receptor activation induces ventriculomegaly and white matter loss. 12151769 2002
CUI: C3278923
Disease: Dilated ventricles (finding)
Dilated ventricles (finding) 		0.200 Biomarker phenotype RGD A1 adenosine receptor activation induces ventriculomegaly and white matter loss. 12151769 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Therapeutic disease CTD_human Role of adenosine in delayed preconditioning of myocardium. 12160945 2002
CUI: C0004096
Disease: Asthma
Asthma 		0.130 Biomarker disease BEFREE Pharmacological approach of translation in asthma includes therapeutic ribozymes and antisense oligonucleotides targeting receptors (adenosine A1 receptor, alpha chain of IL-5 receptor, common beta chain of IL-3/IL-5/GM-CSF receptor), cytokines (IL-4, IL-5, SCF), signal transduction molecules (Syk, Lyn), transcription factors (STAT-6, GATA-3). 14754517 2004