|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
Activating transcription factor 2 (ATF2; also known as cAMP-dependent transcription factor ATF-2) has oncogenic activities in melanoma and tumor suppressor activities in non-malignant skin tumors and breast cancer.
|
22685333 |
2012 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
Emerging roles of ATF2 and the dynamic AP1 network in cancer.
|
20029425 |
2010 |
|
Malignant neoplasm of breast
|
0.370 |
Biomarker
|
disease |
BEFREE |
ATF-2 simultaneously binds to Oct-1, NF-I and breast cancer suppressor BRCA1 to activate transcription.
|
17700520 |
2008 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design.
|
18348191 |
2008 |
|
Malignant neoplasm of breast
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
The ATF-2 mRNA levels in human breast cancers were lower than those in normal breast tissue.
|
17189429 |
2007 |
|
Malignant neoplasm of breast
|
0.370 |
PosttranslationalModification
|
disease |
BEFREE |
These results indicate that spermine can enhance E2-induced cell signaling and cyclin D1 transcription by activation of the p38 MAP kinase and phosphorylation of ATF-2, contributing to breast cancer cell proliferation.
|
16050133 |
2005 |
|
Malignant neoplasm of breast
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the ATF-2 gene were detected in 5 of the 46 (10.6%) lung cancers, but not in neuroblastomas and breast cancers.
|
11836564 |
2002 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
These results indicate a novel role for ATF-2 in cancer cell proliferation and suggest a potential feedback mechanism that regulates MAPK signaling.
|
11062705 |
2000 |
|
Malignant neoplasm of breast
|
0.370 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Benign Neoplasm
|
0.300 |
Biomarker
|
group |
CTD_human |
Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic.
|
23591579 |
2013 |
|
Disease Exacerbation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic.
|
23591579 |
2013 |
|
Meconium Aspiration Syndrome
|
0.210 |
GeneticVariation
|
phenotype |
BEFREE |
Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome.
|
10364225 |
1999 |
|
Meconium Aspiration Syndrome
|
0.210 |
Biomarker
|
phenotype |
MGD |
|
|
|
|
Endotoxemia
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia.
|
24312512 |
2013 |
|
Endotoxemia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.
|
21641970 |
2011 |
|
Glaucoma
|
0.200 |
Biomarker
|
disease |
RGD |
Regulation of cell death and survival pathways in experimental glaucoma.
|
17586494 |
2007 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
RGD |
Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load.
|
11358932 |
2001 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain.
|
10077326 |
1999 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury.
|
9813301 |
1998 |
|
Congenital anomaly of cartilage
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Osteochondrodysplasias
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Leukemia, Myelocytic, Acute
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Notably, we identified that lncRNAs upregulated in AML (relative to the control samples) are associated with a lower degree of DNA methylation and a higher ratio of being bound by transcription factors such as SP1, STAT4, ATF-2 and ELK-1 compared with those downregulated in AML.
|
28203711 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The epsilon isoform of protein kinase C (PKCε) has recently been identified as a master switch that controls the nucleocytoplasmic trafficking of ATF2 and the survival of melanoma cells.
|
30497386 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
SPOP promotes ATF2 ubiquitination and degradation, and ATF2 is an important mediator of SPOP inactivation-induced cell proliferation, migration and invasion.
|
29996942 |
2018 |