|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRP was associated with many other cardiovascular risk factors, particularly markers of obesity and insulin resistance, markers of inflammation and acute phase reaction, and hormone replacement therapy.
|
11448405 |
2001 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results are in agreement with the hypothesis that the synthesis of adipose tissue TNFalpha and leptin could induce the production of interleukin-6, CRP, and other acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation state involved in the progression of obesity and its associated comorbidities.
|
12690081 |
2003 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
C-reactive protein and gestational diabetes: the central role of maternal obesity.
|
12915627 |
2003 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since markers of inflammation are supposed to predict type 2 diabetes, interleukin-6 (IL-6) and C-reactive protein (CRP) in combination with parameters of obesity, insulin resistance and hyperandrogenism were determined in 57 PCOS women and in 20 age-matched healthy controls.
|
15080783 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Previous studies have been unable to control for genetic influences on CRP and obesity.
|
15184288 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In view of the increase in plasma concentrations of proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) in obesity, we investigated whether peripheral blood mononuclear cells (MNC) from obese subjects are in a proinflammatory state.
|
15364812 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that: 1) plasma MIF concentrations and MIF mRNA expression in the MNCs are elevated in the obese, consistent with a proinflammatory state in obesity; 2) these increases in MIF are related to BMI, FFA concentrations, and CRP; 3) metformin suppresses plasma MIF concentrations in the obese, suggestive of an antiinflammatory effect of this drug; and 4) this action of metformin may contribute to a potential antiatherogenic effect, which may have implications for the reduced cardiovascular mortality observed with metformin therapy in type 2 diabetes mellitus.
|
15472203 |
2004 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For 334 normal weight (20 < BMI < or = 25 kg/m2) and 334 obese (BMI > 30 kg/m2) subjects matched by age and sex originating from the population-based EPIC-Potsdam Study, recalled weight change from age 25 to study enrollment was determined, the IL-6 g.-174G>C promoter polymorphism was defined, and plasma concentrations of IL-6 and C-reactive protein were measured.
|
16493118 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obese individuals tend to have elevated C-reactive protein concentrations.
|
16840032 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In adults, markers of subclinical inflammation (C-reactive protein [CRP] and interleukin [IL]-6) and endothelial activation (intracellular adhesion molecule [ICAM]-1) are associated with obesity and higher risk for incident type 2 diabetes.
|
17704300 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The objective of the study was to explore in a population-based sample whether the relation between leptin and CRP is independent of obesity level and whether genetic causes of CRP elevation contribute to leptin levels.
|
17878255 |
2007 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association of the CRP SNPs with endometrial cancer risk and their modification on the association between obesity and endometrial cancer risk were evaluated.
|
18383516 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To assess whether obesity and steatosis potentiate expression of inflammatory markers in chronic HCV, serum protein and hepatic messenger RNA (mRNA) levels of c-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured in 171 patients with chronic HCV.
|
18571785 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IL1B genetic variation may have a role in CRP level regulation and this association may be modified by obesity.
|
18573495 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Common major haplotypes were strongly associated with serum CRP levels, but unrelated to obesity, blood pressure, and socioeconomic position, which may confound the association between CRP and diabetes risk.
|
18700811 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Nonobese offspring with both parents with obesity had higher CRP levels (median 2.16 mg/l) than offspring with one parent (1.58 mg/l) or no parents (1.35 mg/l) with obesity.
|
18931036 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The NWO subjects were found in an intermediate position between the NW and OB subjects in terms of body weight, fat mass percentage (FM%), abdominal FAT%, hs-CRP and plasma triglyceride level.
|
18991689 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
An effect of obesity on CRP level was also noted in haplotype interaction analysis with the association occurring predominantly in obese subjects (P=0.034).
|
19101671 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It has been recognized that obese individuals are intrinsically in a state of chronic inflammation, as indicated by positive correlations between serum levels of C-reactive protein (CRP) and various anthropometric measures of obesity.
|
19238141 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this cohort, mean (SD) habitual sleep duration based on self-report was 7.6 (1.6) h and mean sleep duration by polysomnography (PSG) on the night prior to blood sampling was 6.2 (1.3) h. After adjusting for obesity and apnea severity, each additional hour of habitual sleep duration was associated with an 8% increase in C-reactive protein (CRP) levels (P=0.004) and 7% increase in interleukin-6 (IL-6) levels (P=0.0003).
|
19238807 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationships of RBP4 mRNA expression and circulating protein levels with obesity, anthropometric and metabolic variables, as well as with obesity-related inflammatory markers adiponectin and C-reactive protein.
|
19369430 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study suggests that polymorphisms in IL10, and also possibly in CRP and other genes related to immune response or obesity may be associated with colorectal cancer.
|
19760027 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Boys who carry the GG genotype of CRP +2147 A/G and the CC genotype of IL-6R rs2229238 C/T have a greater risk of having abnormal BW, BMI, WC, HC, BF and WHtR and of developing obesity than individuals who do not have these genotypes.
|
20856253 |
2011 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Further, HNF1A genotypes interact with obesity to set CRP level, revealing that genetic determinants for CRP level may be different between obese and non-obese individuals.
|
21195701 |
2011 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
An effect of obesity on CRP level was also noted in haplotype interaction analysis (interaction P=0.019 for haplotype TACCA).
|
21324310 |
2011 |