CRP, C-reactive protein, 1401

N. diseases: 1483; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Obese individuals tend to have elevated C-reactive protein concentrations. 16840032 2006
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Obesity in patients was associated with a marked increase in IL-6 and CRP levels. 28103807 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Obesity is associated with higher CRP levels and ESR in women with RA. 28393498 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 GeneticVariation disease BEFREE Obesity and COC use were associated with alterations in lipid and inflammatory cardiometabolic parameters, particularly increased CRP levels and decreased HDL-c, which are considered markers of cardiovascular disease (CVD) risk. 29033897 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. 30248505 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases). 31787367 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE CRP was associated with many other cardiovascular risk factors, particularly markers of obesity and insulin resistance, markers of inflammation and acute phase reaction, and hormone replacement therapy. 11448405 2001
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE C-reactive protein and gestational diabetes: the central role of maternal obesity. 12915627 2003
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor. 29910808 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE C-reactive protein (CRP), interleukin (IL)-10, and leptin were all higher in the obese/OSAS group than in controls (P = .004, 0.026, and <0.001, respectively), and compared to OSAS-only patients, CRP (P = .013) and leptin (P = .002) levels were higher in the obese/OSAS group. 31688081 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE CRP but not leukocyte count predicts early anastomotic healing after obesity surgery. 31784329 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 GeneticVariation disease BEFREE A co-twin-control study that allows full control of genetic influence showed that only obesity was significantly associated with higher CRP levels: Odds ratios (95% confidence intervals) were 1.23 (1.04,1.46) for 1 kg/m(2) increase in body mass index and 1.12 (1.03,1.22) for 1% increased in total body fat, respectively. 23360434 2013
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE A series of repeated measure analyses were performed using General Linear Models to discern the effect of obesity on each iron indicator; iron intake, hepcidin, and C-reactive protein were successively introduced as covariates. 30909605 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. 29174028 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE After adjusting for age, sex, fasting plasma glucose level, smoking, and exercise, obesity was associated with sum of dental diseases (ß = 0.239, p = .013), severe periodontitis (OR=4.52; 95% CI 1.37, 14.95, p = .013), adiponectin (ß = -0.359, p < .001), leptin (ß = 0.630, p < .001), and CRP levels (OR=12.66; 95% CI 3.07, 52.21, p < .001). 28513060 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE An effect of obesity on CRP level was also noted in haplotype interaction analysis with the association occurring predominantly in obese subjects (P=0.034). 19101671 2009
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE An effect of obesity on CRP level was also noted in haplotype interaction analysis (interaction P=0.019 for haplotype TACCA). 21324310 2011
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE And CRP and its combination with obesity and hypertension were associated with increased risk of T2DM. 30872696 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Articles measuring serum CRP postoperatively in patients with obesity undergoing bariatric surgery were included. 30895509 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE As many factors linked to obesity can modulate CRP in T2DM, we comprehensively revisited the cardiometabolic phenotype of patients with normal or raised CRP, taking into account the sexual dimorphism of its serum value. 31477553 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein. 30255491 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 GeneticVariation disease BEFREE Boys who carry the GG genotype of CRP +2147 A/G and the CC genotype of IL-6R rs2229238 C/T have a greater risk of having abnormal BW, BMI, WC, HC, BF and WHtR and of developing obesity than individuals who do not have these genotypes. 20856253 2011
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE COH women present abnormalities in non-standard markers of cardiometabolic risk (sRAGE, leptin, high sensitive C-reactive protein), supporting the view that there is no healthy pattern of obesity. 28409494 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Common major haplotypes were strongly associated with serum CRP levels, but unrelated to obesity, blood pressure, and socioeconomic position, which may confound the association between CRP and diabetes risk. 18700811 2008
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Critically, we found that CRP levels statistically mediated the relationships between obesity/greater BMI and working memory, with CRP accounting for 44.1% of the variance explained in working memory by BMI. 31785398 2020