|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression of MUC2 and MUC3 mRNA were both markedly decreased in poorly, moderately, and well-differentiated colon cancers but were preserved in mucinous colon cancers.
|
8813081 |
1996 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer.
|
8020672 |
1994 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
RNA blot analysis and in situ hybridization indicates that MUC17 is expressed in select pancreatic and colon cancer cell lines and in intestinal absorptive cells.
|
11855812 |
2002 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both immunocytochemistry and in situ hybridization were used to identify cell types expressing the MUC2 and MUC3 mucins in the human small intestine, colon, and colon carcinoma.
|
8020672 |
1994 |
|
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
|
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
RNA blot analysis and in situ hybridization indicates that MUC17 is expressed in select pancreatic and colon cancer cell lines and in intestinal absorptive cells.
|
11855812 |
2002 |
|
Ulcerative Colitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This result suggests that rare alleles of the MUC3 gene may confer genetic predisposition to UC.
|
9931338 |
1999 |
|
Ulcerative Colitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We reported a possible association of rare variable number of tandem repeat (VNTR) alleles of the "MUC3" gene with a susceptibility to UC.
|
11289722 |
2001 |
|
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gain- and loss-of-function assays showed that MUC17 inhibited the H. pylori-enhanced GC cell growth by preventing the translocation of H. pylori CagA into GC cells.
|
30778796 |
2019 |
|
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
MUC17 thus inactivated NFκB to inhibit GC cell proliferation in response to pro-inflammatory cytokines.
|
31262330 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In renal carcinoma, we showed a heterogeneous expression of MUC1 and MUC3 with an over-expression of MUC3 in renal clear cell carcinoma.
|
12010365 |
2002 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the kidney, MUC3 is expressed in normal convoluted tubules and in renal clear cell carcinoma.
|
14550470 |
2003 |
|
Hyperplastic Polyp
|
0.020 |
Biomarker
|
disease |
BEFREE |
Improved diagnostic potential was revealed by multivariate logistic regression analysis where combinatorial panel of MUC5AC/MUC17 discriminated SSA/P from HP (SN/SP=85/82%).
|
27705923 |
2017 |
|
Hyperplastic Polyp
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of MUC1, MUC2, and MUC3 core tandem repeat proteins was examined in specimens of normal mucosa (n = 20), hyperplastic polyps (n = 10), adenomatous polyps (n = 89), and invasive cancer (n = 19).
|
8859775 |
1996 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gain- and loss-of-function assays showed that MUC17 inhibited the H. pylori-enhanced GC cell growth by preventing the translocation of H. pylori CagA into GC cells.
|
30778796 |
2019 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
MUC17 thus inactivated NFκB to inhibit GC cell proliferation in response to pro-inflammatory cytokines.
|
31262330 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data demonstrate up-regulated MUC expression by ST cells and suggest a novel role of MUC3 and MUC5AC in the pathogenesis of arthritis.
|
18163520 |
2008 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MUC5AC was expressed at low levels in synovial lining cells, macrophages, and endothelial cells in RA and OA ST, and was barely expressed in normal ST. MUC1 and MUC2 proteins were not detected in ST. Messenger RNA (mRNA) for MUC3 and MUC5AC was detected in ST, and mRNA for MUC3 was detected in cultured ST fibroblasts.
|
18163520 |
2008 |
|
Barrett Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Barrett's oesophagus strongly expressed MUC5AC and MUC3 in the superficial columnar epithelium, MUC2 in the goblet cells, and MUC6 in the glands.
|
11076872 |
2000 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific mucin gene expression was determined using cDNA probes for 2 distinct intestinal mucins (MUC-2 and MUC-3) and one breast cancer mucin (MUC-1).
|
8443822 |
1993 |
|
Bronchioloalveolar Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Non-BAC adenocarcinoma and mucinous BAC aberrantly expressed mucin genes MUC3, and MUC3 and MUC6, respectively, which are undetectable in normal fetal and adult lung.
|
11274635 |
2001 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MUC2 and MUC3 staining intensity in DCIS was markedly less than that observed for MUC1.
|
11348414 |
2001 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The over-expression of MUC3 in renal cell carcinomas favours its implication in renal tumorigenesis.
|
12010365 |
2002 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, mice treated with MUC17-CRD1-L-CRD2 protein given per rectum demonstrated accelerated healing in acetic acid and dextran sodium sulfate induced colitis in vivo.
|
20211273 |
2010 |