|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.
|
12657964 |
2003 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Comparable MUC1, MUC2, and MUC3 mRNA levels were present in adenomas and normal colon, whereas mucin mRNA levels were decreased in adenocarcinomas.
|
8859775 |
1996 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Compared with corresponding normal tissue, MUC1 mRNA levels were increased in breast cancer and well-differentiated lung cancers, and MUC3 mRNA was increased in gastric adenocarcinomas.
|
7678777 |
1993 |
|
Adenocarcinoma of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.
|
12657964 |
2003 |
|
Adenocarcinoma, Clear Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The level of MUC3 expression by in-situ hybridization was associated with the nuclear grade in clear cell carcinoma.
|
12010365 |
2002 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Marked increased expression of MUC17, the cell junction protein genes VSIG1 and GJB5, and the antiapoptotic gene REG4 were found in SSA/Ps, relative to controls and adenomas, were verified by qPCR analysis of additional SSA/Ps (n = 21) and adenomas (n = 10).
|
24533081 |
2014 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Goblet cells expressing the MUC2 gene and columnar cells expressing the MUC3 gene were consistent with an intestinal phenotype, which was observed in 15 tumours (71%) including nine adenomas and six borderline tumours.
|
11241413 |
2001 |
|
Adenomatous Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that enhanced immunoreactivity of MUC1, MUC2 and MUC3 mucin tandem repeats occurs in adenomatous polyps and is associated with an increased risk for malignant transformation.
|
8859775 |
1996 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, AP2alpha and MUC17 were independent markers associated with LNM of PDAC.
|
19817750 |
2010 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data demonstrate up-regulated MUC expression by ST cells and suggest a novel role of MUC3 and MUC5AC in the pathogenesis of arthritis.
|
18163520 |
2008 |
|
Barrett Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Barrett's oesophagus strongly expressed MUC5AC and MUC3 in the superficial columnar epithelium, MUC2 in the goblet cells, and MUC6 in the glands.
|
11076872 |
2000 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific mucin gene expression was determined using cDNA probes for 2 distinct intestinal mucins (MUC-2 and MUC-3) and one breast cancer mucin (MUC-1).
|
8443822 |
1993 |
|
Bronchioloalveolar Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Non-BAC adenocarcinoma and mucinous BAC aberrantly expressed mucin genes MUC3, and MUC3 and MUC6, respectively, which are undetectable in normal fetal and adult lung.
|
11274635 |
2001 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The over-expression of MUC3 in renal cell carcinomas favours its implication in renal tumorigenesis.
|
12010365 |
2002 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest the implication of MUC3 in renal carcinogenesis.
|
14550470 |
2003 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
MUC1, MUC3 and MUC6 were expressed both in normal kidney and in renal carcinomas.
|
12010365 |
2002 |
|
Carcinoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Eight of the genes, APC, TP53, ATM, CSMD3, LRP1B, RYR2, BIRC6, and MUC17, contained mutations in >20% of the carcinomas.
|
29575536 |
2018 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer.
|
8638091 |
1996 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, 13 novel loci (MOB3C‑TMOD4, COL6A3, ADGRL3‑CXCL8‑MARCH1, OR52E4, TCHP‑GIT2, CCDC63, 12q24.1, OAS3, PLCB2‑VPS33B, ZNF77, COL6A5, NFKBIL1‑NCR3, MUC17) were identified that confer susceptibility to early‑onset MI, hypertension, or CKD.
|
30226566 |
2018 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, mice treated with MUC17-CRD1-L-CRD2 protein given per rectum demonstrated accelerated healing in acetic acid and dextran sodium sulfate induced colitis in vivo.
|
20211273 |
2010 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both immunocytochemistry and in situ hybridization were used to identify cell types expressing the MUC2 and MUC3 mucins in the human small intestine, colon, and colon carcinoma.
|
8020672 |
1994 |
|
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
|
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
RNA blot analysis and in situ hybridization indicates that MUC17 is expressed in select pancreatic and colon cancer cell lines and in intestinal absorptive cells.
|
11855812 |
2002 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using high throughput tissue microarray technology we assessed the prognostic value of MUC1 and MUC3 expression in the largest cohort of colorectal cancer patients to date.
|
17349047 |
2007 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In renal carcinoma, we showed a heterogeneous expression of MUC1 and MUC3 with an over-expression of MUC3 in renal clear cell carcinoma.
|
12010365 |
2002 |