Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Compared with corresponding normal tissue, MUC1 mRNA levels were increased in breast cancer and well-differentiated lung cancers, and MUC3 mRNA was increased in gastric adenocarcinomas.
|
7678777 |
1993 |
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
Intestinal metaplasia
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In contrast, high levels of MUC2 and MUC3 mucin mRNA and immunoreactive protein were found in specimens with intestinal metaplasia.
|
7780985 |
1995 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In several samples of moderately well-differentiated colon cancer, MUC2 and MUC3 showed distinct patterns of expression, but the expression level of each was reduced compared with levels in normal tissue; there was considerable tumor-to-tumor and cell-to-cell variability using both mucin antibodies and complementary DNA probes.
|
8020672 |
1994 |
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer.
|
8020672 |
1994 |
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Both immunocytochemistry and in situ hybridization were used to identify cell types expressing the MUC2 and MUC3 mucins in the human small intestine, colon, and colon carcinoma.
|
8020672 |
1994 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific mucin gene expression was determined using cDNA probes for 2 distinct intestinal mucins (MUC-2 and MUC-3) and one breast cancer mucin (MUC-1).
|
8443822 |
1993 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific mucin gene expression was determined using cDNA probes for 2 distinct intestinal mucins (MUC-2 and MUC-3) and one breast cancer mucin (MUC-1).
|
8443822 |
1993 |
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, mucin-core-peptide-specific antibodies and cDNA probes were used to determine the relative expression of mucin genes corresponding to one membrane-bound mucin (MUC1), two intestinal mucins (MUC2 and MUC3), and one tracheobronchial mucin (MUC4) in normal (nonneoplastic) lung, and in lung neoplasms.
|
8638091 |
1996 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer.
|
8638091 |
1996 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer.
|
8638091 |
1996 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Membrane-bound (MUC1) and secretory (MUC2, MUC3, and MUC4) mucin gene expression in human lung cancer.
|
8638091 |
1996 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This work evaluates the expression in lung cancer of the most well characterized mucin genes (MUC1, MUC2, MUC3) and of the recently described MUC4 in lung tissues, to check a correlation between the expression of any particular gene and this tumor.
|
8694545 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In colon cancers, the genetic regulation of MUC2 and MUC3 is different depending on the histological type of tumor.
|
8813081 |
1996 |
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression of MUC2 and MUC3 mRNA were both markedly decreased in poorly, moderately, and well-differentiated colon cancers but were preserved in mucinous colon cancers.
|
8813081 |
1996 |
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The constitutive expression of MUC2 and MUC3 mRNA in inflammatory bowel diseases suggests that these genes may be necessary for maintenance of normal epithelial cell function during inflammation.
|
8813081 |
1996 |
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Comparable MUC1, MUC2, and MUC3 mRNA levels were present in adenomas and normal colon, whereas mucin mRNA levels were decreased in adenocarcinomas.
|
8859775 |
1996 |
Hyperplastic Polyp
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of MUC1, MUC2, and MUC3 core tandem repeat proteins was examined in specimens of normal mucosa (n = 20), hyperplastic polyps (n = 10), adenomatous polyps (n = 89), and invasive cancer (n = 19).
|
8859775 |
1996 |
Adenomatous Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that enhanced immunoreactivity of MUC1, MUC2 and MUC3 mucin tandem repeats occurs in adenomatous polyps and is associated with an increased risk for malignant transformation.
|
8859775 |
1996 |
Malignant transformation
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We conclude that enhanced immunoreactivity of MUC1, MUC2 and MUC3 mucin tandem repeats occurs in adenomatous polyps and is associated with an increased risk for malignant transformation.
|
8859775 |
1996 |
Liver calculus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The markedly proliferated intramural and extramural peribiliary glands in hepatolithiasis frequently expressed MUC3 and MUC6 apomucins and focally expressed MUC2 and MUC5 apomucins.
|
9425917 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although there was no correlation of mucin expression with tumor histology, there was a significant decrease in expression of MUC3 and MUC4 with increasing cancer stage (P < 0.05).
|
9850092 |
1998 |
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additional investigation of MUC3 and MUC4 in ovarian cancers may lead to new approaches for early detection and therapy.
|
9850092 |
1998 |
Ulcerative Colitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This result suggests that rare alleles of the MUC3 gene may confer genetic predisposition to UC.
|
9931338 |
1999 |