|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
|
29471430 |
2018 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we have identified novel variants of VTI1A-TCF7L2 fusion transcripts, including a novel fusion partner gene, RP11-57H14.3, and demonstrated detectable levels in a large fraction of CRC samples, as well as in normal colonic mucosa and other tissue types.
|
24608966 |
2014 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
|
25105248 |
2014 |
|
Colorectal Carcinoma
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.
|
25105248 |
2014 |
|
Colorectal Carcinoma
|
0.420 |
Biomarker
|
disease |
CTD_human |
We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown.
|
21892161 |
2011 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
|
29471430 |
2018 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
|
25105248 |
2014 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma
|
0.300 |
Biomarker
|
group |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma, Oxyphilic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Carcinoma, Cribriform
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Carcinoma, Granular Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma, Tubular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Glioma
|
0.120 |
Biomarker
|
disease |
BEFREE |
Collectively, our study provides summary evidence that common variants in the VTI1A and TCF7L2 genes are associated with risk of breast, colorectal, lung cancer and glioma and highlights the significant role of the VTI1A-TCF7L2 region in the pathogenesis of human cancers.
|
28949031 |
2018 |
|
Glioma
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
|
Glioma
|
0.120 |
Biomarker
|
disease |
BEFREE |
In summary, our results indicate that genetic variants in VTI1A and ETFA may modify individual susceptibility to non-GBM of glioma in the Han Chinese population and support the role of the VTI1A and ETFA genes in the occurrence of glioma.
|
28320150 |
2017 |