|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells.
|
18161931 |
2007 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
In the colon tumors, beta-catenin mutations were detected at a higher frequency after caffeine posttreatment, and there was a shift toward more tumors harboring substitutions of Gly34 with correspondingly high protein and messenger RNA expression seen for both beta-catenin and c-Myc. c-Myc expression exhibited concordance with tumor promotion, and there was a concomitant increase in cell proliferation versus apoptosis in colonic crypts.
|
18283038 |
2008 |
|
Colonic Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
These data indicate that exisulind and analogs activate and induce PKG, resulting in increased phosphorylation of beta-catenin and enhanced apoptosis to promote colon tumor cell death.
|
11602670 |
2001 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We next adapted the chromatin immunoprecipitation assay for use with primary colon tumor samples, and, using matched pairs of normal and tumor tissue obtained from several different colon cancer patients, we demonstrate that levels of beta-catenin bound to the SU(Z)12 promoter are increased in colon tumors.
|
12533679 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase.
|
15459021 |
2005 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PhIP-induced skin tumors were subjected to mutation screening, which identified genetic changes in Hras (7/40, 17.5%) and Tp53 (2/40, 5%), but not in Ctnnb1, a commonly mutated gene in PhIP-induced colon tumors.
|
28218467 |
2017 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.
|
17030184 |
2006 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In a converse experiment, the forced expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased β-catenin stability and CYCLIN-D1 synthesis.
|
21569306 |
2011 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Analysis of β-catenin alterations in colon tumors: a novel exon 3 mutation.
|
20717765 |
2011 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
|
22556201 |
2012 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.
|
22323126 |
2012 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
beta-Catenin signaling in biological control and cancer.
|
17854061 |
2007 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1.
|
17404573 |
2007 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Activation of the β-catenin/T-cell factor (TCF) complex occurs in most colon tumors, and its actions correlate with the neoplastic phenotype of intestinal epithelial cells.
|
22771508 |
2012 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Murine deletion of Cck2r abrogated progastrin-dependent increases in colonic proliferation, mucosal thickness, and beta-catenin and CD44 expression in the colon tumor.
|
19652364 |
2009 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.
|
17128412 |
2007 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1.
|
17404573 |
2007 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In colorectal carcinomas, all 5 of the beta-catenin mutations were found in proximal colon tumors.
|
12912937 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The finding of LOH in ACF with normal expressions of adenomatous polyposis coli (APC) and beta-catenin proteins suggests that LOH can occur very early in colon neoplasia and perhaps even before APC mutations.
|
16474178 |
2006 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.
|
17241872 |
2007 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway.
|
15837931 |
2005 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The mechanism by which sulindac sulfide and the cGMP/PKG pathway inhibits colon tumor cell growth involves the transcriptional suppression of β-catenin to inhibit Wnt/β-catenin T-cell factor transcriptional activity, leading to downregulation of cyclin D1 and survivin.
|
23804703 |
2013 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We also observed the inactivation of β-catenin/TCF signaling after CBB1003 treatment, consistent with the positive correlations among LSD1, LGR5, β-catenin and c-Myc expression in human colon tumor and adenoma tissues.
|
25060070 |
2015 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, mutations in the region corresponding to N-terminal phosphorylation sites (codons 1-51) of the rat Ctnnb1 gene were investigated in 20 colon tumors associated with ulcerative colitis and induced with methylazoxymethanol acetate and 1-hydroxyanthraquinone.
|
10204808 |
1999 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.
|
16378739 |
2006 |