|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
|
22556201 |
2012 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Activation of Apc/beta-catenin/Tcf pathway may play a role in Paneth cell differentiation in human colonic neoplasms.
|
19269007 |
2009 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Activation of the β-catenin/T-cell factor (TCF) complex occurs in most colon tumors, and its actions correlate with the neoplastic phenotype of intestinal epithelial cells.
|
22771508 |
2012 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Analysis of β-catenin alterations in colon tumors: a novel exon 3 mutation.
|
20717765 |
2011 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.
|
12398896 |
2002 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
|
12810642 |
2003 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
beta-Catenin signaling in biological control and cancer.
|
17854061 |
2007 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity.
|
15215241 |
2004 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
14507667 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase.
|
15459021 |
2005 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin.
|
12800193 |
2003 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer.
|
17638895 |
2007 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Frequent gene mutations of beta-catenin and altered cellular localization of the protein are also features of AOM-induced colon tumors in mice.
|
15182426 |
2004 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway.
|
15837931 |
2005 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.
|
22323126 |
2012 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In a converse experiment, the forced expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased β-catenin stability and CYCLIN-D1 synthesis.
|
21569306 |
2011 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, we found that the beta-catenin protein was accumulated in cytoplasm and nuclei of MDF and the frequent beta-catenin gene mutations in the colon tumors.
|
16761624 |
2006 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In colorectal carcinomas, all 5 of the beta-catenin mutations were found in proximal colon tumors.
|
12912937 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In mice, SMAC deficiency significantly increased the incidence and size of colon tumors induced by azoxymethane (AOM)/dextran sulfate sodium salt (DSS), and highly enriched β-catenin hot spot mutations.
|
22751125 |
2013 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
In the colon tumors, beta-catenin mutations were detected at a higher frequency after caffeine posttreatment, and there was a shift toward more tumors harboring substitutions of Gly34 with correspondingly high protein and messenger RNA expression seen for both beta-catenin and c-Myc. c-Myc expression exhibited concordance with tumor promotion, and there was a concomitant increase in cell proliferation versus apoptosis in colonic crypts.
|
18283038 |
2008 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, mutations in the region corresponding to N-terminal phosphorylation sites (codons 1-51) of the rat Ctnnb1 gene were investigated in 20 colon tumors associated with ulcerative colitis and induced with methylazoxymethanol acetate and 1-hydroxyanthraquinone.
|
10204808 |
1999 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).
|
12628520 |
2003 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Murine deletion of Cck2r abrogated progastrin-dependent increases in colonic proliferation, mucosal thickness, and beta-catenin and CD44 expression in the colon tumor.
|
19652364 |
2009 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.
|
17030184 |
2006 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.
|
16378739 |
2006 |