|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
The results provide evidence for a major role of the beta-catenin/Apc pathway in the development of heterocyclic amine-induced colon tumors and give further weight to the view that regulation of beta-catenin is critical to the tumor suppressive effects of Apc during colon carcinogenesis.
|
9515794 |
1998 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, mutations in the region corresponding to N-terminal phosphorylation sites (codons 1-51) of the rat Ctnnb1 gene were investigated in 20 colon tumors associated with ulcerative colitis and induced with methylazoxymethanol acetate and 1-hydroxyanthraquinone.
|
10204808 |
1999 |
|
Colonic Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
These data indicate that exisulind and analogs activate and induce PKG, resulting in increased phosphorylation of beta-catenin and enhanced apoptosis to promote colon tumor cell death.
|
11602670 |
2001 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.
|
12398896 |
2002 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We next adapted the chromatin immunoprecipitation assay for use with primary colon tumor samples, and, using matched pairs of normal and tumor tissue obtained from several different colon cancer patients, we demonstrate that levels of beta-catenin bound to the SU(Z)12 promoter are increased in colon tumors.
|
12533679 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).
|
12628520 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin.
|
12800193 |
2003 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
|
12810642 |
2003 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In colorectal carcinomas, all 5 of the beta-catenin mutations were found in proximal colon tumors.
|
12912937 |
2003 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
14507667 |
2003 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Frequent gene mutations of beta-catenin and altered cellular localization of the protein are also features of AOM-induced colon tumors in mice.
|
15182426 |
2004 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity.
|
15215241 |
2004 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase.
|
15459021 |
2005 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway.
|
15837931 |
2005 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells.
|
16378739 |
2006 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The finding of LOH in ACF with normal expressions of adenomatous polyposis coli (APC) and beta-catenin proteins suggests that LOH can occur very early in colon neoplasia and perhaps even before APC mutations.
|
16474178 |
2006 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, we found that the beta-catenin protein was accumulated in cytoplasm and nuclei of MDF and the frequent beta-catenin gene mutations in the colon tumors.
|
16761624 |
2006 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.
|
17030184 |
2006 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.
|
17128412 |
2007 |
|
Colonic Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.
|
17241872 |
2007 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1.
|
17404573 |
2007 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1.
|
17404573 |
2007 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer.
|
17638895 |
2007 |
|
Colonic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
beta-Catenin signaling in biological control and cancer.
|
17854061 |
2007 |
|
Colonic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells.
|
18161931 |
2007 |