|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in the tumor suppressor adenomatous polyposis coli or beta-catenin is a critical event in the development of human colorectal tumors.
|
12417602 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The prevalence of APC truncation mutants in colorectal tumors and the ability of these alleles to act dominantly to inhibit the mitotic spindle place chromosome instability at the earliest stage of colorectal cancer progression (i.e., prior to deregulation of beta-catenin).
|
19928352 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.
|
21291235 |
2011 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Previous studies have revealed that β‑catenin is associated with TRAIL resistance in melanoma and colorectal tumors.
|
30132512 |
2018 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We therefore used PCR to amplify and sequence exon 3 of beta-catenin from 202 sporadic colorectal tumors.
|
10197610 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
However, about 10% of colorectal tumors also exhibit increased CTNNB1 mRNA.
|
27758879 |
2016 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that somatic beta-catenin activating mutations contribute only to a minor part of human colorectal tumors and that germline beta-catenin mutations do not play a role in the variability of symptoms in FAP.
|
9591632 |
1998 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.
|
23112547 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.
|
14973118 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-β-catenin complex.
|
26619963 |
2016 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.
|
27254743 |
2017 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.
|
15888491 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
ModifyingMutation
|
group |
RGD |
Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats.
|
17893236 |
2008 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The level of Dickkopf-4 was positively correlated with fibroblast growth factor-20 (r(s) = 0.61, P = 0.00017), a representative beta-catenin transcriptional target gene, and with the degree of nuclear accumulation of beta-catenin in colorectal tumors.
|
19659606 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.
|
22108803 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis.
|
15102686 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity.
|
31427737 |
2019 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.
|
11920497 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.
|
25280562 |
2014 |
|
Colorectal Neoplasms
|
0.700 |
PosttranslationalModification
|
group |
LHGDN |
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
|
18538736 |
2008 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
|
18951899 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
|
16356174 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Finally, we show that YAP expression is elevated in the majority of a panel of primary human colorectal tumors compared with its expression in uninvolved colonic mucosa, and that YAP and β-catenin localize to the nuclear compartment of tumor cells.
|
22337891 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.
|
22894902 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer.
|
17203186 |
2007 |