Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1.
|
17291450 |
2007 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth.
|
16953230 |
2007 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Aberrant activation of this signaling pathway is a key early event in the development of colorectal neoplasms, and is mainly caused by loss of function mutations in Adenomatous Polyposis Coli (APC), and less frequently by β-catenin stabilization mutations via missense or interstitial genomic deletions in CTNNB1.
|
30177831 |
2019 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in adenomatous polyposis coli (APC) or beta-catenin is a critical event in the development of human colorectal tumors.
|
12036951 |
2002 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in the tumor suppressor adenomatous polyposis coli or beta-catenin is a critical event in the development of human colorectal tumors.
|
12417602 |
2002 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
|
15331612 |
2004 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Alterations of phosphorylation sites within the CTNNB1 gene, which codes for beta-catenin has been reported to occur in about one-half of colorectal tumors without APC-gene mutations.
|
11454429 |
2001 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Because beta-catenin is constitutively active in the majority of colorectal tumors, it is unlikely that sFRP1 can act in the canonical Wnt response pathway.
|
14871816 |
2004 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer.
|
17203186 |
2007 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients.
|
17641414 |
2007 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors.
|
18992165 |
2008 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Collectively, our data indicate that KDM4B overexpression supports β-catenin mediated gene transcription and thereby contributes to the genesis of colorectal tumors.
|
24481461 |
2014 |
Colorectal Neoplasms
|
0.700 |
PosttranslationalModification
|
group |
LHGDN |
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
|
18538736 |
2008 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups.
|
15126105 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Finally, we show that YAP expression is elevated in the majority of a panel of primary human colorectal tumors compared with its expression in uninvolved colonic mucosa, and that YAP and β-catenin localize to the nuclear compartment of tumor cells.
|
22337891 |
2012 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.
|
21291235 |
2011 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
10493496 |
1999 |
Colorectal Neoplasms
|
0.700 |
ModifyingMutation
|
group |
RGD |
Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats.
|
17893236 |
2008 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
However, about 10% of colorectal tumors also exhibit increased CTNNB1 mRNA.
|
27758879 |
2016 |
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.
|
22894902 |
2012 |
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Increased triplex DNA-binding activity in vitro correlates with lymph node disease, metastasis, and reduced overall survival in colorectal cancer, and increased U2AF65 expression is associated with total and truncated beta-catenin expression in high-stage colorectal tumors.
|
22682314 |
2012 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the levels of Tbeta-4 mRNA, beta-catenin, c-Myc, and MMP-7 in metastatic liver lesions were relatively higher, whereas the levels of E-cadherin and Fas were significantly lower than those in the matched primary colorectal tumors.
|
15235586 |
2004 |
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.
|
19134005 |
2009 |