|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation.
|
28388562 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
β-Catenin, a core component of Wnt/β-catenin signaling, has been shown to be a crucial factor in a broad range of tumors, while its role in glioma is not well understood.
|
20300972 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, SND1 and β-catenin expressions were positively correlated with glioma grades and Ki-67 index, but inversely correlated with miR-320a expression and patients' survival.
|
28160566 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to characterize the mechanism behind cross-talk between GRβ and β-catenin/TCF in the progression of glioma.
|
25301232 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, we aimed to investigate NCTD as an anti-neoplastic drug that inhibits the Wnt/β‑catenin pathway via promoter demethylation of Wnt inhibitory factor-1 (WIF-1) in glioma growth in vitro.
|
26781164 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to identify a concrete mechanism of Wnt/beta-catenin pathway regulation by microRNAs (miRNAs) in glioma.
|
23416699 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth.
|
24931370 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we studied phosphoY142 (PY142) β-catenin and dephospho S/T β-catenin (a classical Wnt transducer) in glioma biopsies, GBM cell lines and biopsy-derived glioma cell cultures.
|
26654598 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As we demonstrated earlier that α5β1 integrin may be considered as a therapeutic target in high grade glioma through its contribution to glioma cell migration and resistance to chemotherapy, we addressed here the potential relationship between α5β1 integrin and beta-catenin activation in glioma cells.
|
27613837 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma.
|
31171769 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-139-5p/Flt1/Wnt/β-catenin regulatory crosstalk modulates the progression of glioma.
|
29393392 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that the MGMT expression was effectively downregulated by 20(S)-Rg3 via the Wnt/β-catenin pathway in glioma cell lines, and TMZ resistance was significantly reversed by 20(S)-Rg3.
|
30431207 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Cancer Genome Atlas (TCGA) data sets indicated diminished CD47, PKM2, and β-catenin levels in IDH1-MT gliomas compared to IDH1-WT gliomas.
|
29463646 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression.
|
24863942 |
2014 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AURKA governs self-renewal capacity in glioma-initiating cells via stabilization/activation of β-catenin/Wnt signaling.
|
23761169 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1.
|
25681036 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, silencing β-catenin recapitulated the cellular and molecular effects seen upon miR-188 overexpression, which included inhibiting glioma cell proliferation and G1-S transition.
|
29268818 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway.
|
27166258 |
2016 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid receptor β regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/TCF transcriptional activity.
|
23906498 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Due to its capacity to counteract β-catenin and glioma cell proliferation and migration, pioglitazone represents a promising drug for adjuvant therapy of glioma and other highly migratory tumor entities.
|
21221726 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIGNIFICANCE: These findings identify the β-catenin-USP1-EZH2 signaling axis as a critical mechanism for glioma tumorigenesis that may serve as a new therapeutic target in glioblastoma.
|
30425057 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Astrocyte Elevated Gene-1 Regulates β-Catenin Signaling to Maintain Glioma Stem-like Stemness and Self-Renewal.
|
27903708 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of clinical specimens verified a positive correlation between Fra1 and β-catenin as well as a poor prognosis in glioma patients with double-high expressions of them.
|
28232512 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results provide the first demonstration of SCAI downregulation in glioma, and its downregulation contributes to increased glioma cell invasion and self-renewal by activating the Wnt/β-catenin pathway.
|
24785374 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate a novel Wnt/β-catenin-miR-30a-5p-NCAM regulatory axis which plays important roles in controlling glioma cell invasion and tumorigenesis.
|
26255203 |
2015 |