CTNNB1, catenin beta 1, 1499

N. diseases: 1368; N. variants: 68
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.100 GeneticVariation disease BEFREE Cytokines related to glioma risk (P ≤ .05) more than 10 years before diagnosis are sIL10RB, VEGF, beta-Catenin and CCL22. 28594935 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation. 28388562 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE β-Catenin, a core component of Wnt/β-catenin signaling, has been shown to be a crucial factor in a broad range of tumors, while its role in glioma is not well understood. 20300972 2011
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE The aim of this study was to characterize the mechanism behind cross-talk between GRβ and β-catenin/TCF in the progression of glioma. 25301232 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Accordingly, we aimed to investigate NCTD as an anti-neoplastic drug that inhibits the Wnt/β‑catenin pathway via promoter demethylation of Wnt inhibitory factor-1 (WIF-1) in glioma growth in vitro. 26781164 2016
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE In the present study, we aimed to identify a concrete mechanism of Wnt/beta-catenin pathway regulation by microRNAs (miRNAs) in glioma. 23416699 2013
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth. 24931370 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Here we studied phosphoY142 (PY142) β-catenin and dephospho S/T β-catenin (a classical Wnt transducer) in glioma biopsies, GBM cell lines and biopsy-derived glioma cell cultures. 26654598 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE As we demonstrated earlier that α5β1 integrin may be considered as a therapeutic target in high grade glioma through its contribution to glioma cell migration and resistance to chemotherapy, we addressed here the potential relationship between α5β1 integrin and beta-catenin activation in glioma cells. 27613837 2016
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma. 31171769 2019
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE MicroRNA-139-5p/Flt1/Wnt/β-catenin regulatory crosstalk modulates the progression of glioma. 29393392 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE We found that the MGMT expression was effectively downregulated by 20(S)-Rg3 via the Wnt/β-catenin pathway in glioma cell lines, and TMZ resistance was significantly reversed by 20(S)-Rg3. 30431207 2019
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression. 24863942 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1. 25681036 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway. 27166258 2016
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Due to its capacity to counteract β-catenin and glioma cell proliferation and migration, pioglitazone represents a promising drug for adjuvant therapy of glioma and other highly migratory tumor entities. 21221726 2011
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE SIGNIFICANCE: These findings identify the β-catenin-USP1-EZH2 signaling axis as a critical mechanism for glioma tumorigenesis that may serve as a new therapeutic target in glioblastoma. 30425057 2019
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Astrocyte Elevated Gene-1 Regulates β-Catenin Signaling to Maintain Glioma Stem-like Stemness and Self-Renewal. 27903708 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Analysis of clinical specimens verified a positive correlation between Fra1 and β-catenin as well as a poor prognosis in glioma patients with double-high expressions of them. 28232512 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Taken together, our results provide the first demonstration of SCAI downregulation in glioma, and its downregulation contributes to increased glioma cell invasion and self-renewal by activating the Wnt/β-catenin pathway. 24785374 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Our findings demonstrate a novel Wnt/β-catenin-miR-30a-5p-NCAM regulatory axis which plays important roles in controlling glioma cell invasion and tumorigenesis. 26255203 2015
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE MicroRNA-362-3p Targets PAX3 to Inhibit the Development of Glioma through Mediating Wnt/β-Catenin Pathway. 31167206 2019
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE We used computational target gene prediction, <i>in vitro</i> cell culture, immunoblotting, quantitative real-time PCR, ATP measurements, luciferase reporter assays, wound-healing assays, Transwell assays, RNA immunoprecipitation PCR, co-immunoprecipitation, flow cytometry and tumor xenografts to study the regulation of the PKM2/β-catenin axis in glioma. 28858851 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. 20888802 2010
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4. 21636708 2011