|
Glioma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, enhanced expression of sFRPs inhibits the motility of glioma cells in vitro. sFRP-mediated effects on glioma cells are accompanied by decreased expression and activity of matrix metalloproteinase-2 (MMP-2) and decreased tyrosine phosphorylation of beta-catenin.
|
10980594 |
2000 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing EGFRvIII in U87Delta cultures with this virus reduced the expression of factors involved in epithelial-mesenchymal transition including N-cadherin, beta-catenin, Snail, Slug, and paxillin but not E-cadherin.
|
19001441 |
2008 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
β-Catenin, a core component of Wnt/β-catenin signaling, has been shown to be a crucial factor in a broad range of tumors, while its role in glioma is not well understood.
|
20300972 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription.
|
20888802 |
2010 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the Wnt/β-catenin pathway regulates glioma cell proliferation and invasion, in part via the EGFR pathway.
|
20969832 |
2010 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Due to its capacity to counteract β-catenin and glioma cell proliferation and migration, pioglitazone represents a promising drug for adjuvant therapy of glioma and other highly migratory tumor entities.
|
21221726 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4.
|
21636708 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide compelling evidence that β-catenin regulation of miR-21 via STAT3 plays a role in glioma cell invasion and proliferation and indicate that STAT3 is a potential therapeutic target for glioma intervention.
|
22630347 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Eps8 modulated the levels of phosphorylated extracellular signal-regulated protein kinase (ERK), phosphorylated serine-threonine protein kinase Akt and β-catenin expression in glioma cell lines and tissues.
|
23229386 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to identify a concrete mechanism of Wnt/beta-catenin pathway regulation by microRNAs (miRNAs) in glioma.
|
23416699 |
2013 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AURKA governs self-renewal capacity in glioma-initiating cells via stabilization/activation of β-catenin/Wnt signaling.
|
23761169 |
2013 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid receptor β regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/TCF transcriptional activity.
|
23906498 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results provide the first demonstration of SCAI downregulation in glioma, and its downregulation contributes to increased glioma cell invasion and self-renewal by activating the Wnt/β-catenin pathway.
|
24785374 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression.
|
24863942 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings demonstrate that endogenous PTPRU promote glioma progression through their effect on β-catenin and focal adhesion signaling.
|
24876153 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have shown that many molecular mechanisms, such as the EGFR, AKT, STAT3, and beta-catenin pathways, are involved in glioma.
|
24913705 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth.
|
24931370 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to characterize the mechanism behind cross-talk between GRβ and β-catenin/TCF in the progression of glioma.
|
25301232 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-155 contributes to the progression of glioma by enhancing Wnt/β-catenin pathway.
|
25672607 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1.
|
25681036 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Wnt activity, evidenced by nuclear β-catenin in our cohort and high expression of its target AXIN2 (axis inhibitor protein 2) in published glioma datasets, was associated with shorter patient survival, although this was not statistically significant.
|
26222502 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate a novel Wnt/β-catenin-miR-30a-5p-NCAM regulatory axis which plays important roles in controlling glioma cell invasion and tumorigenesis.
|
26255203 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma.
|
26317904 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consistently, MAGI3 overexpression in glioma cells C6 suppressed expression of β-catenin target genes including Cyclin D1 and Axin2, whereas MAGI3 knockdown in glioma cells U373 and LN229 enhanced their expression.
|
26452219 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we studied phosphoY142 (PY142) β-catenin and dephospho S/T β-catenin (a classical Wnt transducer) in glioma biopsies, GBM cell lines and biopsy-derived glioma cell cultures.
|
26654598 |
2015 |